微小RNA作为神经退行性疾病的生物标志物。

miRNAs as biomarkers of neurodegenerative disorders.

作者信息

Viswambharan Vijitha, Thanseem Ismail, Vasu Mahesh M, Poovathinal Suresh A, Anitha Ayyappan

机构信息

Department of Neurogenetics, Institute for Communicative & Cognitive Neurosciences (ICCONS), Shoranur, Palakkad 679 523, Kerala, India.

Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan.

出版信息

Biomark Med. 2017 Feb;11(2):151-167. doi: 10.2217/bmm-2016-0242. Epub 2017 Jan 26.

DOI:10.2217/bmm-2016-0242

PMID:28125293

Abstract

Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons, ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing therapies are mainly aimed at treating the most bothersome symptoms. Since early treatment is crucial in NDDs, there is an urgent need for specific and sensitive biomarkers that can aid in early diagnosis of these disorders. Recently, altered expression of miRNAs has been implicated in several neurological disorders, including NDDs. miRNA expression has been extensively investigated in the cells, tissues and body fluids of patients with different types of NDDs. The aim of this review is to provide a comprehensive overview of miRNAs as biomarkers and therapeutic targets for NDDs.

摘要

神经退行性疾病（NDDs）是神经元进行性退化的结果，最终导致残疾。目前尚无治疗NDDs的有效方法；现行疗法主要旨在治疗最困扰人的症状。由于早期治疗对NDDs至关重要，因此迫切需要能够辅助这些疾病早期诊断的特异性和敏感性生物标志物。最近，miRNA表达的改变与包括NDDs在内的几种神经疾病有关。在不同类型NDDs患者的细胞、组织和体液中，miRNA表达已得到广泛研究。本综述的目的是全面概述miRNA作为NDDs的生物标志物和治疗靶点的情况。