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[视网膜成像技术作为基层医疗中慢性青光眼早期诊断筛查方法的应用评估:针对有开角型青光眼危险因素人群的筛查验证]

[Assessment of the use of retinography as a screening method for the early diagnosis of chronic glaucoma in Primary Care: Validation for screening in populations with open-angle glaucoma risk factors].

作者信息

Sánchez González Soraya, Calvo Lozano José, Sánchez González Jessica, Pedregal González Miguel, Cornejo Castillo Manuel, Molina Fernández Eduardo, Barral Francisco Javier, Pérez Espinosa José Ramón

机构信息

Medicina Familiar y Comunitaria, Consultorio de Santa Bárbara de Casa, Unidad de Gestión Clínica Andévalo Occidental, Santa Bárbara de Casa, Huelva, España.

Medicina Familiar y Comunitaria, Unidad de Gestión Clínica El Molino de la Vega, Huelva, España.

出版信息

Aten Primaria. 2017 Aug-Sep;49(7):399-406. doi: 10.1016/j.aprim.2016.10.008. Epub 2017 Jan 23.

Abstract

OBJECTIVE

The aim of this study is to determine usefulness, validity of retinographies performed in Primary Care as a tool for early diagnosis of open-angle chronic glaucoma (OAG).

DESIGN

An observational, descriptive and cross-sectional study with two blinded parallel observers: 2 general practitioners and 1 ophthalmologist.

LOCATION

Urban Primary Care Health Centre, and the Ophthalmology Department outpatient clinic.

PARTICIPANTS

A total of 196 patients of both genders, between 40-70years, with diabetes and hypertension, and undiagnosed with glaucoma, were recruited by phone call after checking patient lists. Two patients that did not arrive for their appointments for the ophthalmology tests were considered as losses.

MEASUREMENTS

For the quantitative diagnostic variable of glaucoma: Accuracy calculated from the sensitivity and specificity, safety from the positive and negative predictive values and the positive and negative probability ratio; interobserver concordance by Kappa index ratio and the intraclass correlation (IC).

RESULTS

The retinography for OAG screening has a sensitivity of 21% (95%CI: 0-43%), a specificity of 93% (95%CI: 89-97%), a negative predictive value of 94% (95%CI: 90-97%), and positive of 20% (95%CI: 0-40%); positive probability ratio of 3.07 (95%CI: 0.98-9.62) and negative 0.84 (95%CI: 0.64-1.11). The IC was 0.653 (95%CI: 0.495-0.769) and kappa index of 0.140 (0.106ET).

CONCLUSIONS

According to this proposed model, retinography is not a useful tool for the early diagnosis of OAG in Primary Care, as it is not safe enough. Before it can be used, it would need adjustments for its low sensitivity, and the use other combined tests. The training of general practitioners would also need to be improved.

摘要

目的

本研究旨在确定在初级保健中进行视网膜成像作为开角型慢性青光眼(OAG)早期诊断工具的实用性和有效性。

设计

一项观察性、描述性和横断面研究,有两名盲法平行观察者:2名全科医生和1名眼科医生。

地点

城市初级保健健康中心和眼科门诊。

参与者

通过检查患者名单后电话招募了总共196名年龄在40至70岁之间、患有糖尿病和高血压且未被诊断为青光眼的男女患者。两名未前来进行眼科检查预约的患者被视为失访。

测量

对于青光眼的定量诊断变量:根据敏感性和特异性计算准确性,根据阳性和阴性预测值以及阳性和阴性概率比计算安全性;通过Kappa指数比和组内相关性(IC)计算观察者间一致性。

结果

用于OAG筛查的视网膜成像敏感性为21%(95%可信区间:0 - 43%),特异性为93%(95%可信区间:89 - 97%),阴性预测值为94%(95%可信区间:90 - 97%),阳性预测值为20%(95%可信区间:0 - 40%);阳性概率比为3.07(95%可信区间:0.98 - 9.62),阴性概率比为0.84(95%可信区间:0.64 - 1.11)。IC为0.653(95%可信区间:0.495 - 0.769),Kappa指数为0.140(0.106ET)。

结论

根据该模型,视网膜成像在初级保健中并非OAG早期诊断的有用工具,因为其安全性不足。在使用之前,需要针对其低敏感性进行调整,并使用其他联合检查。全科医生的培训也需要改进。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/951f/6875967/cef48db499b7/fx1.jpg

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