Nádasdy T, Iványi B, Orvos H, Bodrogi T, Csajbók E, Marofka F, Ormos J
Orv Hetil. 1989 Oct 29;130(44):2369-73.
This is the first report on the recurrence of a glomerular disease in renal transplant in Hungary. The primary disease of the girl died at the age of 13 was focal sclerosing glomerulonephritis with slight mesangial cell proliferation. The first symptoms appeared at the age of 6.5 and they progressed rapidly. Four years later, because of the severe nephrotic syndrome and chronic renal failure, renal transplantation was performed with the synchronous removal of the patient's own kidneys. In the latter an interesting immunohistological finding has been observed: beside the usual positivities, the basement membrane of the distal tubule at the opposite side of the macula densa showed a strong reaction with anti IgM and a somewhat weaker positivity with anti C3 sera. The primary disease recurred very soon. A mesangial cell proliferation, however did not develop, in contrary to the primary disease, which contradicts the theory that the mesangioproliferative form would be a distinct clinicopathological entity.
这是匈牙利关于肾移植中肾小球疾病复发的首篇报道。该女孩13岁时因原发性疾病去世，其原发性疾病为伴有轻微系膜细胞增殖的局灶节段性肾小球硬化。最初症状于6.5岁时出现，且进展迅速。四年后，由于严重的肾病综合征和慢性肾衰竭，在切除患者自身双肾的同时进行了肾移植。在其自身双肾中观察到一个有趣的免疫组织学发现：除了常见的阳性反应外，致密斑对侧远端小管的基底膜对抗IgM血清呈现强反应，对抗C3血清呈现稍弱的阳性反应。原发性疾病很快复发。然而，与原发性疾病不同，并未出现系膜细胞增殖，这与系膜增生性形式是一种独特的临床病理实体这一理论相矛盾。
