Komorowska Olivia, Bohdan Michal, Szczerkowska-Dobosz Aneta, Rawicz-Zegrzda Dorota, Dudziak Maria, Zdrojewski Tomasz, Gruchala Marcin, Purzycka-Bohdan Dorota, Nowicki Roman
Szczerkowska-Dobosz Aneta, MD, PhD, 7th Debinki St., 80-211 Gdansk, Poland;
Acta Dermatovenerol Croat. 2016 Dec;24(4):261-267.
Psoriasis is a chronic inflammatory skin disorder associated with increased cardiovascular risk. Aim of this work was to evaluate the association between psoriasis and chosen cardiovascular risk factors, echocardiographic parameters, and carotid intima-media thickness. A total of 50 patients with psoriasis and 50 controls were enrolled in the study. Psoriasis area severity index was calculated in the study group. Systolic and diastolic blood pressure, body mass index, waist circumference, lipids, fasting glucose, and D-dimer levels were assessed in all patients. In addition, echochardiographic parameters and carotid intima-media thickness were measured. Patients with psoriasis had higher blood pressure (P=0.001), elevated triglycerides (P=0.0218), lower high-density lipoprotein cholesterol (HDL-C) (P=0.0014), elevated D-dimer levels (p=0.0009), and were more frequently overweight (P=0.0198) in comparison to controls. There were no differences in echocardiographic parameters and carotid intima-media thickness between the psoriasis and control groups. Moreover, a positive correlation between psoriasis area severity index and blood pressure was observed (P=0.0088). The study confirmed that psoriasis is associated with increased cardiovascular risk. The association between psoriasis, intima-media thickness, and echocardiographic parameters should be evaluated in large prospective studies.
银屑病是一种慢性炎症性皮肤病，与心血管疾病风险增加相关。本研究的目的是评估银屑病与所选心血管危险因素、超声心动图参数及颈动脉内膜中层厚度之间的关联。共有50例银屑病患者和50例对照者纳入本研究。在研究组中计算银屑病面积严重程度指数。对所有患者评估收缩压和舒张压、体重指数、腰围、血脂、空腹血糖及D - 二聚体水平。此外，测量超声心动图参数和颈动脉内膜中层厚度。与对照组相比，银屑病患者血压更高（P = 0.001）、甘油三酯升高（P = 0.0218）、高密度脂蛋白胆固醇（HDL - C）降低（P = 0.0014）、D - 二聚体水平升高（P = 0.0009），且超重更为常见（P = 0.0198）。银屑病组与对照组在超声心动图参数和颈动脉内膜中层厚度方面无差异。此外，观察到银屑病面积严重程度指数与血压之间存在正相关（P = 0.0088）。该研究证实银屑病与心血管疾病风险增加相关。银屑病、内膜中层厚度及超声心动图参数之间的关联应在大型前瞻性研究中进行评估。
