Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
Department of Pathology, University Regensburg, Regensburg, Germany.
Sci Rep. 2017 Jan 27;7:41429. doi: 10.1038/srep41429.
Gd-EOB-DTPA, a liver-specific contrast agent with T1-shortening effects, is routinely used in clinical routine for detection and characterization of focal liver lesions and has recently received increasing attention as a tool for the quantitative analyses of liver function. We report the relationship between the extent of Gd-EOB-DTPA- induced T1 relaxation and the degree of liver fibrosis, which was assessed according to the METAVIR score. For the T1 relaxometry, a transverse 3D VIBE sequence with inline T1 calculation was acquired prior to and 20 minutes after Gd-EOB-DTPA administration. The reduction rates of the T1 relaxation time (rrT1) between the pre- and postcontrast images were calculated, and the optimal cutoff values for the fibrosis stages were determined with receiver operating characteristic (ROC) curve analyses. The rrT1 decreased with the severity of liver fibrosis and regression analysis revealed a significant correlation of the rrT1 with the stage of liver fibrosis (r = -0.906, p < 0.001). ROC analysis revealed sensitivities ≥78% and specificities ≥94% for the differentiation of different fibrosis stages. Gd-EOB-DTPA-enhanced T1 relaxometry is a reliable tool for both the detection of initial hepatic fibrosis and the staging of hepatic fibrosis.
钆塞酸二钠（Gd-EOB-DTPA）是一种具有 T1 缩短效应的肝脏特异性对比剂，常用于临床检测和诊断局灶性肝脏病变，最近作为一种肝脏功能定量分析工具也受到越来越多的关注。我们报告了 Gd-EOB-DTPA 诱导的 T1 弛豫程度与肝脏纤维化程度之间的关系，肝脏纤维化程度是根据 METAVIR 评分来评估的。在 T1 弛豫测量中，在 Gd-EOB-DTPA 给药前后分别采集了横向 3D VIBE 序列和在线 T1 计算。计算对比前后 T1 弛豫时间（rrT1）的减少率，并通过接收者操作特性（ROC）曲线分析确定纤维化分期的最佳截断值。rrT1 随着肝脏纤维化的严重程度而降低，回归分析显示 rrT1 与肝脏纤维化分期之间存在显著相关性（r = -0.906，p < 0.001）。ROC 分析显示，对于不同纤维化分期的区分，灵敏度≥78%，特异性≥94%。Gd-EOB-DTPA 增强 T1 弛豫测量是一种可靠的工具，可用于检测早期肝纤维化和分期肝纤维化。
