Verloh Niklas, Utpatel Kirsten, Haimerl Michael, Zeman Florian, Fellner Claudia, Fichtner-Feigl Stefan, Teufel Andreas, Stroszczynski Christian, Evert Matthias, Wiggermann Philipp
Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
Department of Pathology, University Hospital Regensburg, Regensburg, Germany.
Sci Rep. 2015 Oct 19;5:15408. doi: 10.1038/srep15408.
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 minutes after contrast injection. Strong correlations of the uptake characteristics of Gd-EOB-DTPA with the relative enhancement (RE) of the liver parenchyma and the grade of fibrosis/cirrhosis, classified using the Ishak scoring system, were observed. The subdivisions between the grades of liver fibrosis based on RE were highly significant for all combinations, and a ROC revealed sensitivities ≥82% and specificities ≥87% for all combinations. MR imaging is a satisfactorily sensitive method for the assessment of liver fibrosis/cirrhosis.
钆乙氧基苄基二乙三胺五乙酸（Gd-EOB-DTPA）是一种肝细胞特异性磁共振成像（MRI）造影剂。由于Gd-EOB-DTPA的肝脏摄取取决于肝细胞团的完整性，因此这种摄取可以进行量化以评估肝功能。我们报告了Gd-EOB-DTPA摄取程度与肝纤维化程度之间的关系。在注射造影剂前及注射后20分钟采集了具有脂肪抑制功能的T1加权容积内插屏气检查（VIBE）序列。观察到Gd-EOB-DTPA的摄取特征与肝实质的相对强化（RE）以及使用Ishak评分系统分类的纤维化/肝硬化分级之间存在强相关性。基于RE的肝纤维化分级之间的细分对于所有组合都具有高度显著性，并且一项ROC曲线分析显示所有组合的敏感性≥82%，特异性≥87%。磁共振成像对于评估肝纤维化/肝硬化是一种敏感性令人满意的方法。
