Cibičková Ľubica, Karásek David
Vnitr Lek. 2016 Fall;62(11):919-923.
According to current knowledge, uric acid plays an important role in pathogenesis of civilizational diseases - obesity, metabolic syndrome and cardiovascular diseases. Uric acid has become an independent risk factor of morbidity and mortality. It is questionable, if the relationship between uric acid and cardiovascular diseases is direct (through influence on endothelial dysfunction, oxidative stress and inflammation) or indirect (mediated by known risk factors of cardiovascular diseases - metabolic syndrome, obesity, insulin resistance and hypertension). This article describes relationship between particular cardiovascular risk factors and uric acid. However, on the basis of current knowledge it is not possible to recommend treatment of hyperuricemia in order to decrease cardiovascular risk.Key words: fructose - insulin resistance - metabolic syndrome - uric acid - visceral obesity.
根据目前的认识，尿酸在文明病——肥胖、代谢综合征和心血管疾病的发病机制中起重要作用。尿酸已成为发病和死亡的独立危险因素。尿酸与心血管疾病之间的关系是直接的（通过影响内皮功能障碍、氧化应激和炎症）还是间接的（由心血管疾病的已知危险因素——代谢综合征、肥胖、胰岛素抵抗和高血压介导），这是值得怀疑的。本文描述了特定心血管危险因素与尿酸之间的关系。然而，根据目前的认识，为降低心血管风险而推荐治疗高尿酸血症是不可能的。关键词：果糖——胰岛素抵抗——代谢综合征——尿酸——内脏肥胖
