Manfredini Roberto, De Giorgi Alfredo, Tiseo Ruana, Boari Benedetta, Cappadona Rosaria, Salmi Raffaella, Gallerani Massimo, Signani Fulvia, Manfredini Fabio, Mikhailidis Dimitri P, Fabbian Fabio
1 University of Ferrara , Ferrara, Italy .
2 Azienda Ospedaliera-Universitaria (AOU) , Ferrara, Italy .
J Womens Health (Larchmt). 2017 Jun;26(6):624-632. doi: 10.1089/jwh.2016.6103. Epub 2017 Jan 27.
There is evidence showing that marital status (MS) and marital disruption (i.e., separation, divorce, and being widowed) are associated with poor physical health outcomes, including for all-cause mortality. We checked for the available evidence on the association between MS and cardiovascular (CV) diseases, outcomes, and CV risk factors.
A search across the PubMed database of all articles, including the term "marital status" in their title, was performed. All articles were then manually checked for the presence of the following terms or topic: CV diseases, acute myocardial infarction, acute coronary syndrome, coronary artery disease, cardiac arrest, heart failure, heart diseases, and CV mortality. Moreover, other search terms were: CV risk factors, hypertension, cholesterol, obesity, smoking, alcohol, fitness and/or physical activity, and health. Systematic reviews, meta-analyses, controlled trials, cohort studies, and case-control studies were potentially considered pertinent for inclusion. Case reports, comments, discussion letters, abstracts of scientific conferences, articles in other than English language, and conference abstracts or proceedings were excluded.
In total, 817 references containing the title words "marital status" were found. After elimination of articles dealing with other topics, 70 records were considered pertinent. Twenty-two were eliminated for several reasons, such as old articles, no abstract, full text unavailable, other than English language, comments, and letters. Out of the remaining 48 articles, 13 were suitable for the discussion, and 35 (accounting for 1,245,967 subjects) were included in this study.
Most studies showed better outcomes for married persons, and men who were single generally had the poorest results. Moreover, being married was associated with lower risk factors and better health status, even in the presence of many confounding effects.
有证据表明婚姻状况（MS）和婚姻关系破裂（即分居、离婚和丧偶）与包括全因死亡率在内的身体健康状况不佳有关。我们查阅了关于MS与心血管（CV）疾病、结局及CV危险因素之间关联的现有证据。
在PubMed数据库中搜索所有标题中包含“婚姻状况”一词的文章。然后人工检查所有文章是否包含以下术语或主题：CV疾病、急性心肌梗死、急性冠状动脉综合征、冠状动脉疾病、心脏骤停、心力衰竭、心脏病和CV死亡率。此外，其他搜索词包括：CV危险因素、高血压、胆固醇、肥胖、吸烟、饮酒、健身和/或体育活动以及健康。系统评价、荟萃分析、对照试验、队列研究和病例对照研究可能被认为适合纳入。病例报告、评论、讨论信、科学会议摘要、非英语文章以及会议摘要或会议记录均被排除。
总共找到817篇包含标题词“婚姻状况”的参考文献。在排除涉及其他主题的文章后，70条记录被认为相关。由于一些原因，如文章年代久远、无摘要、无法获取全文、非英语、评论和信件等，22条记录被排除。在其余48篇文章中，13篇适合讨论，35篇（涉及1,245,967名受试者）被纳入本研究。
大多数研究表明已婚者的结局更好，而单身男性的结果通常最差。此外，即使存在许多混杂效应，结婚也与较低的危险因素和更好的健康状况相关。
