Toresson Linda, Steiner Joerg M, Olmedal Gunilla, Larsen MajBritt, Suchodolski Jan S, Spillmann Thomas
1 Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, Helsinki University, Helsinki, Finland.
2 Evidensia Specialist Animal Hospital, Helsingborg, Sweden.
J Feline Med Surg. 2017 Dec;19(12):1302-1306. doi: 10.1177/1098612X16689406. Epub 2017 Jan 27.
Objectives The objective of the study was to evaluate whether oral cobalamin supplementation can restore normocobal-aminaemia in cats with hypocobalaminaemia and clinical signs of gastrointestinal disease. Methods This was a retrospective study based on a computerised database search for client-owned cats treated at Evidensia Specialist Animal Hospital, Helsingborg, Sweden, during the period December 2013 to August 2016. Inclusion criteria were cats with clinical signs of chronic enteropathy, an initial serum cobalamin concentration ⩽250 pmol/l (reference interval 214-738 pmol/l) and oral treatment with cobalamin tablets. Results Twenty-five cats met the inclusion criteria. The cats were treated with 0.25 mg cyanocobalamin tablets once daily. Serum cobalamin concentration was rechecked 27-94 days after continuous oral cobalamin supplementation. All cats had serum cobalamin concentrations above the reference interval after oral cobalamin supplementation. Median (range) serum cobalamin concentration was 128 pmol/l (111-250 pmol/l) prior to treatment and 2701 pmol/l (738-16,359 pmol/l) after supplementation. This difference was statistically significant ( P <0.0001). Conclusions and relevance Our results suggest that oral cobalamin supplementation is effective in increasing serum cobalamin to supranormal concentrations in cats with hypocobalaminaemia. Thus, oral cobalamin supplementation is a promising alternative to parenteral administration. Prospective comparative studies in cats being treated with parenteral vs oral cobalamin supplementation in a larger number of patients are warranted before oral supplementation can be recommended for routine use.
目的 本研究的目的是评估口服钴胺素补充剂能否使患有低钴胺血症及胃肠道疾病临床症状的猫恢复正常钴胺素血症。方法 这是一项回顾性研究，基于对2013年12月至2016年8月期间在瑞典赫尔辛堡的Evidensia专科动物医院接受治疗的客户拥有的猫进行计算机数据库搜索。纳入标准为患有慢性肠病临床症状、初始血清钴胺素浓度≤250 pmol/l（参考区间214 - 738 pmol/l）且接受钴胺素片口服治疗的猫。结果 25只猫符合纳入标准。这些猫每天服用一次0.25毫克氰钴胺片。在持续口服钴胺素补充剂27 - 94天后重新检查血清钴胺素浓度。口服钴胺素补充剂后，所有猫的血清钴胺素浓度均高于参考区间。治疗前血清钴胺素浓度中位数（范围）为128 pmol/l（111 - 250 pmol/l），补充后为2,701 pmol/l（738 - 16,359 pmol/l）。这种差异具有统计学意义（P < 0.0001）。结论及相关性 我们的结果表明，口服钴胺素补充剂可有效提高低钴胺血症猫的血清钴胺素浓度至超正常水平。因此，口服钴胺素补充剂是肠外给药的一个有前景的替代方法。在推荐口服补充剂用于常规使用之前，有必要对更多患者进行肠外与口服钴胺素补充治疗的猫的前瞻性比较研究。
