Stoppe G, Wildhagen K, Meyer G J, Schober O
Neurologischen Klinik mit klinischer Neurophysiologie, Hannover, BRD.
Nuklearmedizin. 1989 Oct;28(5):187-92.
Central nervous system involvement has been found in 30-75% of all cases of systemic lupus erythematosus (SLE). Up to now, clinical diagnosis is difficult and there are no markers for disease activity. We have compared cranial computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodesoxyglucose (FDG) in two cases. FDG-PET is shown to be the most sensitive method demonstrating even reversible deficits and a better correlation with other neurological findings. MRI seems to be more sensitive than CT. A survey of the literature concerning imaging methods in neuropsychiatric SLE is given. The special problem of neuronal desactivation by antineuronal activity is discussed.
在所有系统性红斑狼疮（SLE）病例中，30%至75%的患者存在中枢神经系统受累情况。到目前为止，临床诊断困难，且尚无疾病活动的标志物。我们对两例患者使用氟脱氧葡萄糖（FDG）进行了头颅计算机断层扫描（CT）、磁共振成像（MRI）和正电子发射断层扫描（PET）的比较。结果显示，FDG-PET是最敏感的方法，甚至能显示可逆性缺陷，且与其他神经学检查结果具有更好的相关性。MRI似乎比CT更敏感。本文对神经精神性SLE的影像学检查方法相关文献进行了综述。还讨论了抗神经元活性导致神经元失活这一特殊问题。
