Csépány T, Gulyás B, Trón L, Szakáll S, Kiss E, Kollár J, Sikula J, Szegedi G, Csiba L
Debreceni Orvostudományi Egyetem, Neurológiai Klinika.
Orv Hetil. 1997 Aug 3;138(31):1947-52.
The cerebral glucose metabolism in eight patients with systemic lupus erythematosus (SLE) and in five healthy controls were examined by positron emission tomography (PET) using 18-F-labeled deoxy-glucose (FDG) as tracer. One of the eight patients had no abnormality by magnetic resonance imaging (MRI), three of them had cerebral atrophy and four patients had multiple white matter hyperintensities and vascular infarcts in the striatum as assessed by MRI. With FDG-PET, inhomogeneous multifocal cerebral glucose hypometabolism was detected, more frequently in the temporal lobe of right hemisphere. The PET findings did not correlate always with the neurological symptoms. Abnormalities in brain metabolism can be detected more frequently by PET, than morphological changes by MRI, indicating the involvement of the central nervous system.
采用正电子发射断层扫描（PET）技术，以18-F标记的脱氧葡萄糖（FDG）作为示踪剂，对8例系统性红斑狼疮（SLE）患者和5名健康对照者的脑葡萄糖代谢情况进行了检查。8例患者中1例经磁共振成像（MRI）检查无异常，3例有脑萎缩，4例经MRI评估有多发白质高信号及纹状体血管梗死。通过FDG-PET检测到不均匀多灶性脑葡萄糖代谢减低，在右颞叶更为常见。PET检查结果并不总是与神经症状相关。与MRI显示的形态学改变相比，PET能更频繁地检测到脑代谢异常，提示中枢神经系统受累。
