[Effect of electrical damage to catecholaminergic structures on aggressiveness in rats following administration of isoniazide].

The author studied the effect of INH administered in single and repeated doses on affective aggressiveness. INH's effect on predatory aggressiveness was evaluated following administration of the drug in a single dose in three different doses. Affective aggressiveness was provoked by pain stimulus, predatory aggression by chronic isolation. In order to evaluate the role of catecholaminergic neurons in INH's effect on affective aggression, electrical damage of structures known to have such neurons was carried out. INH was administered in a single and in multiple doses increasing affective aggressiveness in rats. This was intensified by destruction of the nucleus locus coeruleus and decreased by destroying ventral parts of the noradrenergic and dopaminergic pathways of the A-10 structure. INH decreased predatory aggressiveness of rats. The results of this study demonstrate the role of catecholamines in INH influence on aggression, showing also different roles of both studied neurological structures in regulation of aggression in rats.