Chojnowski K, Feltynowski T, Wocial B, Chodakowska J, Filipecki S, Januszewicz W
Pol Tyg Lek. 1989;44(12-13):280-4.
The use of prazosin--a drug selectively blocking alpha-adrenergic receptors--was considered for the preoperative management of patients with phaeochromocytoma. Prazosin was administered to 8 patients in whom the diagnosis was established basing on the clinical symptoms and daily excretion of catecholamines and their metabolites with the urine. Preliminary diagnosis was subsequently confirmed operationally. Prazosin could be considered effective only in the part of treated patients. This was manifested by the drop in blood pressure to nearly normal values and diminished attacks. However, prazosin did not prevent blood pressure increase during anaesthesia and surgery. The use of prazosin in patients with phaeochromocytoma for preoperative management may be an alternative pharmacological therapy producing appropriate drop in blood pressure in some patients.
曾考虑使用哌唑嗪（一种选择性阻断α-肾上腺素能受体的药物）对嗜铬细胞瘤患者进行术前管理。对8例根据临床症状以及儿茶酚胺及其代谢产物的每日尿排泄量确诊的患者给予了哌唑嗪。初步诊断随后经手术得到证实。哌唑嗪仅在部分接受治疗的患者中被认为有效。这表现为血压降至接近正常水平且发作次数减少。然而，哌唑嗪并未防止麻醉和手术期间血压升高。在嗜铬细胞瘤患者中使用哌唑嗪进行术前管理可能是一种替代药物疗法，可使部分患者的血压适当下降。
