Sasaki M, Takenawa J, Kanamaru H, Komatz Y
Hinyokika Kiyo. 1986 Jan;32(1):61-6.
We used prazosin (alpha-blocker) for preoperative management of three patients with pheochromocytoma. All patients had episodic hypertension with headache and palpitation. The first dose of prazosin caused blood pressure to drop in one of three patients, but no significant hypotension was observed. By the daily dose of 6-8 mg prazosin with or without propranolol, subjective symptoms of the patients were improved and the frequency of the hypertensive attack was decreased Operations were carried out without significant complications, but phentramine and nitroprusside were required because of rapid rise of blood pressure during induction of anesthesia and surgical manipulation.
我们使用哌唑嗪（一种α受体阻滞剂）对3例嗜铬细胞瘤患者进行术前管理。所有患者均有发作性高血压伴头痛和心悸。3例患者中有1例在服用首剂哌唑嗪后出现血压下降，但未观察到明显的低血压情况。通过每日给予6 - 8毫克哌唑嗪，无论是否联合普萘洛尔，患者的主观症状均得到改善，高血压发作频率降低。手术进行过程中未出现明显并发症，但在麻醉诱导和手术操作期间，由于血压迅速升高，需要使用酚妥拉明和硝普钠。
