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[缺血性心脏病患者的T淋巴细胞亚群]

[Subpopulations of t lymphocytes in patients with ischemic heart disease].

作者信息

Skopińska-Rózewska E, Liszewska-Pfejfert D, Małkowska-Zwierz W, Pawińska M, Polakowski I J, Wróblewski T

出版信息

Pol Tyg Lek. 1989 Feb 6;44(6):147-9.

PMID:2813169
Abstract

T-cells subpopulations were determined with theophylline test in 42 patients with the ischemic heart disease, including 31 patients with the history of myocardial infarction, and in 78 healthy volunteers. The patients' age was between 20 and 40 years and between 60 and 80 years. Defect of theophylline-sensitive fraction (suppressor T-cells and cytotoxically not specific lymphocytes in young patients has been observed. This defect gradually diminished with patients' age. Moreover, and increase in the percentage of theophylline-resistant fraction of the delayed rosettes, containing among other helper T-cells for the production of antibodies, and a decrease in the percentage of early rosette fraction containing precursor cells have been noted in the group of young patients. This defect is normalized in the group of older patients.

摘要

对42例缺血性心脏病患者(其中31例有心肌梗死病史)以及78名健康志愿者进行了茶碱试验,以确定T细胞亚群。患者年龄在20至40岁之间以及60至80岁之间。观察到年轻患者中茶碱敏感部分(抑制性T细胞和细胞毒性非特异性淋巴细胞)存在缺陷。随着患者年龄增长,这种缺陷逐渐减轻。此外,在年轻患者组中,含有产生抗体的辅助性T细胞等的迟发型玫瑰花结的茶碱抵抗部分百分比增加,而含有前体细胞的早期玫瑰花结部分百分比下降。在老年患者组中,这种缺陷恢复正常。

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