Armitage Emily Grace, Ciborowski Michal
Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad CEU San Pablo, Campus Monteprincipe, Madrid, Spain.
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow, UK.
Adv Exp Med Biol. 2017;965:209-234. doi: 10.1007/978-3-319-47656-8_9.
Since the start of metabolomics as a field of research, the number of studies related to cancer has grown to such an extent that cancer metabolomics now represents its own discipline. In this chapter, the applications of metabolomics in cancer studies are explored. Different approaches and analytical platforms can be employed for the analysis of samples depending on the goal of the study and the aspects of the cancer metabolome being investigated. Analyses have concerned a range of cancers including lung, colorectal, bladder, breast, gastric, oesophageal and thyroid, amongst others. Developments in these strategies and methodologies that have been applied are discussed, in addition to exemplifying the use of cancer metabolomics in the discovery of biomarkers and in the assessment of therapy (both pharmaceutical and nutraceutical). Finally, the application of cancer metabolomics in personalised medicine is presented.
自代谢组学作为一个研究领域兴起以来，与癌症相关的研究数量增长到了如此程度，以至于癌症代谢组学如今已自成一门学科。在本章中，将探讨代谢组学在癌症研究中的应用。根据研究目的和所研究的癌症代谢组方面，可以采用不同的方法和分析平台来分析样本。分析涉及一系列癌症，包括肺癌、结直肠癌、膀胱癌、乳腺癌、胃癌、食管癌和甲状腺癌等。除了举例说明癌症代谢组学在生物标志物发现和治疗评估（包括药物治疗和营养治疗）中的应用外，还将讨论已应用的这些策略和方法的进展。最后，介绍癌症代谢组学在个性化医疗中的应用。
