Suresh T P
Indian J Physiol Pharmacol. 1978 Jul-Sep;22(3):249-62.
Electrocardiographic (ECG) amplitude changes during clinically feasible rate of infusion of normal saline (NS), Ringer-Locke (RL) solution and tender coconut water (TCW) upto a dose of 100 ml/kg in paraldehyde (PLD) and chloralose and urethane (C&U) anaesthetised dogs were studied. The infusion caused a net decrease in P and QRS amplitudes but had varied effect on T wave amplitude in intact PLD and C&U anaesthetised dogs. Infusion of RL in vagotomised and/or carotid sinus (CS) denervated dogs and in spinal dogs indicated that these neural pathways had a significant effect on basal amplitude of ECG waves but their influence on infusion induced ECG changes was only marginal; in this the vagi seem to have a greater influence than the other pathways. The T wave changes during infusion were independent of simultaneous P and QRS changes and appeared to depend on the ionic composition of the infusion fluid. TCW infusion was very well tolerated, particularly by the C&U anaesthetised dogs. It would seem that the evaluation of ECG from patients on parenteral fluid be done in the context of the present observation that infusion per se decreases the amplitude of ECG.
研究了在副醛（PLD）以及水合氯醛和氨基甲酸乙酯（C&U）麻醉的犬中，以临床可行的输注速率输注生理盐水（NS）、林格液（RL）和嫩椰子水（TCW）直至剂量达100 ml/kg时的心电图（ECG）幅度变化。在完整的PLD和C&U麻醉犬中，输注导致P波和QRS波幅度净下降，但对T波幅度有不同影响。在迷走神经切断和/或颈动脉窦（CS）去神经支配的犬以及脊髓犬中输注RL表明，这些神经通路对ECG波的基础幅度有显著影响，但它们对输注引起的ECG变化的影响仅为边缘性；在这方面，迷走神经似乎比其他通路有更大的影响。输注期间的T波变化与同时出现的P波和QRS波变化无关，似乎取决于输注液的离子组成。TCW输注耐受性良好，尤其是C&U麻醉的犬。鉴于目前观察到输注本身会降低ECG幅度，似乎应对接受胃肠外补液患者的ECG进行评估。
