Tsukamoto Yukika, Oshima Hisami, Katsumori Takashi, Hamaguchi Hiromitsu, Yamamoto Shinichi, Iwanaga Tomohiro, Ohkawara Susumu
Dept. of Surgery, Arao Mumicipal Hospital.
Gan To Kagaku Ryoho. 2016 Nov;43(12):2112-2114.
The patient was a 70-year-old woman with a gastrointestinalstromaltumor (GIST)of the small intestine and synchronous colonic cancer, who underwent laparoscopic right colectomy and resection of the small intestine. We started imatinib therapy because GIST belongs to a high-risk group, according to the modified Fletcher classification. Gastric cancer was diagnosed 2 years after the start of imatinib therapy. Only 4 of the 12 GIST cases seen at our institution over the last 5 years were complicated by another cancer. This is the first case of GIST in which 2 other cancers occurred at both the same and different times. We suggest that imatinib might be a factor in the development of gastric cancer.
该患者为一名70岁女性,患有小肠胃肠道间质瘤(GIST)并伴有同步性结肠癌,接受了腹腔镜右半结肠切除术和小肠切除术。根据改良的弗莱彻分类,由于GIST属于高危组,我们开始了伊马替尼治疗。在伊马替尼治疗开始2年后诊断出胃癌。在过去5年里,我们机构所见的12例GIST病例中,只有4例并发了另一种癌症。这是首例在同一时间和不同时间均发生另外两种癌症的GIST病例。我们认为伊马替尼可能是胃癌发生的一个因素。