Kondo Junya, Chijimatsu Hikari, Kijima Taiki, Nagashima Yukiko, Hayashi Hideto, Morita Katsuhiko, Sakata Kouichiro, Setoguchi Mihoko
Dept. of Digestive Surgery, Japan Community Health care Organization(JCHO)Shimonoseki Medical Center.
Gan To Kagaku Ryoho. 2018 Mar;45(3):515-517.
A 78-year-old woman was diagnosed with a gastrointestinal stromal tumor(GIST)of the stomach, gradually increasing from 5 years prior. The tumor was suspected to invade the pancreatic body tail and spleen, as observed with computed tomography. Because the patient refused to undergo resection, we administered imatinib mesylate for 6 years. Since early rectal cancer was revealed, the patient was referred for resection and underwent laparoscopic low anterior resection and partial gastrectomy. Histopathologically, the tumor was replaced by tissues with myxomatous changes, and no viable tumor cells were detected. This was a rare case of GIST, resected after long-term chemotherapy by imatinib mesylate, and pathological complete response was achieved.
一名78岁女性被诊断为胃胃肠间质瘤（GIST），自5年前起逐渐增大。计算机断层扫描显示，该肿瘤疑似侵犯胰体尾部和脾脏。由于患者拒绝接受手术切除，我们给予甲磺酸伊马替尼治疗6年。后来发现患者患有早期直肠癌，遂转诊进行手术切除，患者接受了腹腔镜低位前切除术和部分胃切除术。组织病理学检查显示，肿瘤被黏液样变的组织取代，未检测到存活的肿瘤细胞。这是一例罕见的GIST病例，在长期接受甲磺酸伊马替尼化疗后进行了手术切除，并实现了病理完全缓解。
