Koga Chikato, Murakami Masahiro, Shimizu Junzo, Yasuyama Akinobu, Matsumura Tae, Kameda Chizu, Kawabata Ryohei, Oda Naofumi, Hirota Masaki, Yoshikawa Masato, Morishima Hirotaka, Noura Shingo, Matsunami Nobuki, Hasegawa Junichi
Dept. of Surgery, Osaka Rosai Hospital.
Gan To Kagaku Ryoho. 2016 Nov;43(12):2356-2358.
The patient was a 79-year-old man, who underwent left nephrectomy for left renal cell carcinoma in 2007. In March 2015, he complained ofthirst, polydipsia, and polyuria. A slight elevation ofamylase levels was detected following laboratory testing. Abdominal CT revealed well-enhanced tumors in the pancreatic head and tail. MPD was dilated in the pancreatic body and tail. Endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)was used to obtain additional pathological findings. We diagnosed multiple pancreatic metastases from renal cell carcinoma using cell block sections from EUS-FNA ofthe pancreatic head tumor. We also identified worsening of diabetes control due to pancreatic disease. A subtotal stomachsparing pancreaticoduodenectomy and a distal pancreatectomy were performed in June 2015. Histological examination confirmed clear cell carcinoma metastases from RCC in both tumors. The patient remains alive without recurrence approximately 1 year after surgery. Glycemic control has improved with a decrease in insulin levels. Cell block sections from EUS-FNA are useful in the diagnosis of pancreatic disease. Although postoperative follow-up ofthe remnant pancreas is important, preservation ofthe pancreas should be considered for multiple pancreatic metastases when complete tumor removal is possible.
该患者为一名79岁男性,2007年因左肾细胞癌接受了左肾切除术。2015年3月,他出现口渴、多饮和多尿症状。实验室检查发现淀粉酶水平略有升高。腹部CT显示胰头和胰尾有强化良好的肿瘤。胰体和胰尾的主胰管扩张。采用内镜超声引导下细针穿刺活检(EUS-FNA)获取更多病理结果。我们通过对胰头肿瘤进行EUS-FNA的细胞块切片诊断为肾细胞癌的多发胰腺转移。我们还发现由于胰腺疾病导致糖尿病控制恶化。2015年6月进行了保留部分胃的胰十二指肠切除术和远端胰腺切除术。组织学检查证实两个肿瘤均为肾细胞癌的透明细胞癌转移。患者术后约1年仍存活且无复发。随着胰岛素水平降低,血糖控制得到改善。EUS-FNA的细胞块切片对胰腺疾病的诊断很有用。尽管对残余胰腺进行术后随访很重要,但当有可能完全切除肿瘤时,对于多发胰腺转移应考虑保留胰腺。