3' noncoding region of phosphoenolpyruvate carboxykinase mRNA contains a glucocorticoid-responsive mRNA-stabilizing element.
作者信息
Petersen D D, Koch S R, Granner D K
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232.
出版信息
Proc Natl Acad Sci U S A. 1989 Oct;86(20):7800-4. doi: 10.1073/pnas.86.20.7800.
Abstract
The stabilization of phosphoenolpyruvate carboxykinase mRNA by glucocorticoids appears to result from the interaction of an induced factor with an RNA element located in the 3' noncoding sequence of the mRNA. This element can confer glucocorticoid-dependent stabilization upon a heterologous mRNA, and thus strategies developed to investigate the control of mRNA transcription can now be applied to the analysis of hormone-regulated mRNA stabilization.
摘要
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