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3' noncoding region of phosphoenolpyruvate carboxykinase mRNA contains a glucocorticoid-responsive mRNA-stabilizing element.

作者信息

Petersen D D, Koch S R, Granner D K

机构信息

Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232.

出版信息

Proc Natl Acad Sci U S A. 1989 Oct;86(20):7800-4. doi: 10.1073/pnas.86.20.7800.

DOI:10.1073/pnas.86.20.7800
PMID:2813358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC298158/
Abstract

The stabilization of phosphoenolpyruvate carboxykinase mRNA by glucocorticoids appears to result from the interaction of an induced factor with an RNA element located in the 3' noncoding sequence of the mRNA. This element can confer glucocorticoid-dependent stabilization upon a heterologous mRNA, and thus strategies developed to investigate the control of mRNA transcription can now be applied to the analysis of hormone-regulated mRNA stabilization.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/298158/b60a98940ba4/pnas00287-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/298158/b60a98940ba4/pnas00287-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7ef/298158/b60a98940ba4/pnas00287-0151-a.jpg

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本文引用的文献

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Commitment of chick oviduct tubular gland cells to produce ovalbumin mRNA during hormonal withdrawal and restimulation.在激素撤去和重新刺激过程中，鸡输卵管管状腺细胞产生卵清蛋白mRNA的情况。
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Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid.新形成的缺乏聚腺苷酸的信使核糖核酸进入细胞质和多核糖体，但在缺乏聚腺苷酸的情况下半衰期较短。
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环磷酸腺苷（cAMP）和糖皮质激素对大鼠下丘脑器官型培养物中室旁核小细胞神经元血管加压素基因表达的调控
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Regulation of tyrosine aminotransferase gene expression by glucocorticoids in quiescent and regenerating liver.糖皮质激素对静止和再生肝脏中酪氨酸转氨酶基因表达的调控
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Binding of a protein to an AU-rich domain of tumour necrosis factor alpha mRNA as a 35 kDa complex and its regulation in primary rat astrocytes.一种蛋白质以35 kDa复合物形式与肿瘤坏死因子α mRNA富含AU的区域结合及其在原代大鼠星形胶质细胞中的调控。
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Modifications of RNA processing modulate the expression of hemoglobin genes.RNA 加工的修饰调节血红蛋白基因的表达。
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