Darnell J E
Nature. 1982 Jun 3;297(5865):365-71. doi: 10.1038/297365a0.
In light of present progress in the understanding of how messenger RNA is constructed in eukaryotic cells, the levels of gene control are discussed. Transcriptional control, assessed by the rate of synthesis of specific nuclear RNA, is strongly indicated to be the most frequent level of control. Definition of eukaryotic transcription units as simple (encoding one protein) and complex (encoding two or more proteins) affords a framework in which to discuss control at the level of RNA processing for which several examples also are known. Finally, differential stability of cytoplasmic mRNAs and differential translation, both well established, are briefly described.
鉴于目前在真核细胞中信使核糖核酸（mRNA）构建方式的理解上取得的进展，本文讨论了基因控制的各个层面。通过特定核RNA的合成速率评估的转录控制，被有力地表明是最常见的控制层面。将真核转录单位定义为简单型（编码一种蛋白质）和复合型（编码两种或更多种蛋白质），提供了一个框架，用以讨论在RNA加工层面的控制，对此也有若干已知实例。最后，简要描述了细胞质mRNA的差异稳定性和差异翻译，这两者都已得到充分证实。
