Wang Xin, Hu Rui, Wang Yirong, Yan Qiang, Wang Yihan, Kang Fei, Zhu Shouping
School of Life Science and Technology, Xidian University, Xi'an, China.
Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Xi'an, China.
Front Oncol. 2021 Dec 21;11:786289. doi: 10.3389/fonc.2021.786289. eCollection 2021.
When performing the diffuse optical tomography (DOT) of the breast, the mismatch between the forward model and the experimental conditions will significantly hinder the reconstruction accuracy. Therefore, the reference measurement is commonly used to calibrate the measured data before the reconstruction. However, it is complicated to customize corresponding reference phantoms based on the breast shape and background optical parameters of different subjects in clinical trials. Furthermore, although high-density (HD) DOT configuration has been proven to improve imaging quality, a large number of source-detector (SD) pairs also increase the difficulty of multi-channel correction. To enhance the applicability of the breast DOT, a data self-calibration method based on an HD parallel-plate DOT system is proposed in this paper to replace the conventional relative measurement on a reference phantom. The reference predicted data can be constructed directly from the measurement data with the support of the HD-DOT system, which has nearly a hundred sets of measurements at each SD distance. The proposed scheme has been validated by Monte Carlo (MC) simulation, breast-size phantom experiments, and clinical trials, exhibiting the feasibility in ensuring the quality of the DOT reconstruction while effectively reducing the complexity associated with relative measurements on reference phantoms.
在进行乳腺扩散光学层析成像（DOT）时，正向模型与实验条件之间的不匹配会显著阻碍重建精度。因此，在重建之前，通常使用参考测量来校准测量数据。然而，在临床试验中，根据不同受试者的乳房形状和背景光学参数定制相应的参考体模很复杂。此外，尽管高密度（HD）DOT配置已被证明可提高成像质量，但大量的源探测器（SD）对也增加了多通道校正的难度。为提高乳腺DOT的适用性，本文提出一种基于HD平行板DOT系统的数据自校准方法，以取代在参考体模上进行的传统相对测量。在HD-DOT系统的支持下，参考预测数据可直接从测量数据构建，该系统在每个SD距离处有近百组测量值。所提方案已通过蒙特卡罗（MC）模拟、乳房尺寸体模实验和临床试验得到验证，显示出在确保DOT重建质量的同时有效降低与参考体模相对测量相关复杂性的可行性。
