氮杂双环类抗肿瘤药物阿齐霉素生物合成的引发作用。

Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents.

作者信息

Mori Shogo, Nepal Keshav K, Kelly Gilbert T, Sharma Vasudha, Simkhada Dinesh, Gowda Vishruth, Delgado Dioscar, Watanabe Coran M H

机构信息

Department of Chemistry, Texas A&M University , College Station, Texas 77843, United States.

出版信息

Biochemistry. 2017 Feb 14;56(6):805-808. doi: 10.1021/acs.biochem.6b01108. Epub 2017 Feb 6.

DOI:10.1021/acs.biochem.6b01108

PMID:28135072

Abstract

The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the "crown jewel" of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.

摘要

氮杂霉素家族抗肿瘤药物氮杂双环体系的生物合成是该途径的“皇冠上的明珠”，是一个涉及至少14个酶促步骤的复杂过程。本研究报道了新型氮丙啶并[1,2-a]吡咯烷氮杂双环核心构建过程中的首个生物合成步骤及进展，这使我们能够支持氮杂双环形成的新机制。