Song Yun-Mi, Sung Joohon, Lee Kayoung
1 Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University , School of Medicine, Seoul, South Korea .
2 Department of Epidemiology, School of Public Health, Seoul National University , Seoul, South Korea .
Metab Syndr Relat Disord. 2017 Apr;15(3):124-129. doi: 10.1089/met.2016.0100. Epub 2017 Jan 30.
We evaluated the association between changes in adiposity traits including anthropometric and fat mass indicators and changes in metabolic syndrome traits including metabolic syndrome clustering and individual components over time. We also assessed the shared genetic and environmental correlations between the two traits.
Participants were 284 South Korean twin individuals and 279 nontwin family members had complete data for changes in adiposity traits and metabolic syndrome traits of the Healthy Twin study. Mixed linear model and bivariate variance-component analysis were applied.
Over a period of 3.1 ± 0.6 years of study, changes in adiposity traits [body mass index (BMI), waist circumference, total fat mass, and fat mass to lean mass ratio] had significant associations with changes in metabolic syndrome clustering [high blood pressure, high serum glucose, high triglycerides (TG), and low high-density lipoprotein cholesterol] after adjusting for intra-familial and sibling correlations, age, sex, baseline metabolic syndrome clustering, and socioeconomic factors and health behaviors at follow-up. Change in BMI associated significantly with changes in individual metabolic syndrome components compared to other adiposity traits. Change in metabolic syndrome component TG was a better predictor of changes in adiposity traits compared to changes in other metabolic components. These associations were explained by significant environmental correlations but not by genetic correlations.
Changes in anthropometric and fat mass indicators were positively associated with changes in metabolic syndrome clustering and those associations appeared to be regulated by environmental influences.
我们评估了包括人体测量和脂肪量指标在内的肥胖特征变化与包括代谢综合征聚集和个体组分在内的代谢综合征特征随时间变化之间的关联。我们还评估了这两种特征之间共享的遗传和环境相关性。
参与者为284名韩国双胞胎个体以及279名非双胞胎家庭成员，他们拥有健康双胞胎研究中肥胖特征和代谢综合征特征变化的完整数据。应用了混合线性模型和双变量方差成分分析。
在为期3.1±0.6年的研究期间，在调整家族内和同胞相关性、年龄、性别、基线代谢综合征聚集以及随访时的社会经济因素和健康行为后，肥胖特征[体重指数（BMI）、腰围、总脂肪量和脂肪量与瘦体重比]的变化与代谢综合征聚集[高血压、高血糖、高甘油三酯（TG）和低高密度脂蛋白胆固醇]的变化存在显著关联。与其他肥胖特征相比，BMI的变化与个体代谢综合征组分的变化显著相关。与其他代谢组分的变化相比，代谢综合征组分TG的变化是肥胖特征变化的更好预测指标。这些关联由显著的环境相关性而非遗传相关性所解释。
人体测量和脂肪量指标的变化与代谢综合征聚集的变化呈正相关，且这些关联似乎受环境影响调节。
