长春花生物碱的修饰：一种源自17-脱乙酰长春碱的内酯。
Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.
作者信息
De Bruyn A, Verzele M, Dejonghe J P, Bhushana Rao K S, Collard M P, Trouet A, Hannart J
出版信息
Planta Med. 1989 Aug;55(4):364-6. doi: 10.1055/s-2006-962029.
PMID:2813571
Abstract
A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.
摘要
在多聚甲醛与17-去乙酰长春碱的反应过程中形成了一种具有抗肿瘤活性的螺内酯。该化合物通过核磁共振技术进行鉴定。对其化疗活性进行了评估。
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