来自柯氏止泻木的细胞毒性和杀利什曼原虫氨基糖苷类化合物及氨基甾体化合物。

Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii.

作者信息

Kam T S, Sim K M, Koyano T, Toyoshima M, Hayashi M, Komiyama K

机构信息

Department of Chemistry, University of Malaya, 59100 Kuala Lumpur, Malaysia.

出版信息

J Nat Prod. 1998 Nov;61(11):1332-6. doi: 10.1021/np970545f.

DOI:10.1021/np970545f

PMID:9834146

Abstract

The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epi-holacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3alpha-amino-14beta-hydroxypregnan-20-one (7), and 15alpha-hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N-demethylholacurtine (2), and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.

摘要

柯氏止泻木叶片的乙醇提取物除了已知化合物止泻木碱（1）、N -去甲基止泻木碱（2）和止泻木胺（6）之外，还产生了五种新的甾体生物碱：17 -表止泻木亭（3）、17 -表-N -去甲基止泻木亭（4）、止泻木醇（5）、3α-氨基-14β-羟基孕甾-20 -酮（7）和15α-羟基止泻木胺（8）。所有这八种化合物均表现出显著的细胞毒性和抗利什曼原虫活性。