Tsuzuki K, Yanai A, Tange I, Bandoh Y
Department of Plastic Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Plast Reconstr Surg. 1989 Nov;84(5):789-93. doi: 10.1097/00006534-198911000-00012.
We investigated the relationship between the survival rate of experimental rat pedicle island flaps and mild vascular insufficiency, using a flap designed to induce constant distant necrosis. To eliminate individual variation, the vasculature of each flap was evaluated by injecting dye prior to ligating either or both of the pedicle vessels. Seventy-five male Wistar rats divided into four groups were used. Six of the rats died, so 69 rats were evaluated. Statistically, the dye distance of each group was the same. In the control group of 29 rats, survival length was directly proportional to dye distance. Although the mean values of the survival length minus the dye distance of each flap (delta S.L.) in the venous inadequacy group were not different from those of the control group, there was significant difference between the mean values of the arterial insufficiency and the venous inadequacy plus arterial insufficiency groups and those of the control group. In the pedicle island flap, mild venous inadequacy was less responsible for necrosis when the arterial inflow was sufficient. However, when the arterial inflow was impaired, even mild venous inadequacy affected flap survival.
我们使用一种设计用于诱发持续性远端坏死的皮瓣，研究了实验大鼠带蒂岛状皮瓣存活率与轻度血管功能不全之间的关系。为消除个体差异，在结扎一根或两根蒂血管之前，通过注射染料来评估每个皮瓣的血管系统。使用了75只雄性Wistar大鼠，分为四组。其中6只大鼠死亡，因此对69只大鼠进行了评估。统计学上，每组的染料扩散距离相同。在29只大鼠的对照组中，存活长度与染料扩散距离成正比。虽然静脉功能不全组每个皮瓣的存活长度减去染料扩散距离（δS.L.）的平均值与对照组无差异，但动脉功能不全组以及静脉功能不全加动脉功能不全组的平均值与对照组之间存在显著差异。在带蒂岛状皮瓣中，当动脉血流充足时，轻度静脉功能不全对坏死的影响较小。然而，当动脉血流受损时，即使是轻度静脉功能不全也会影响皮瓣存活。
