脉搏波速度与冠状动脉狭窄及经皮冠状动脉介入治疗的关系：一项回顾性观察研究。

The Relationship between Pulse Wave Velocity and Coronary Artery Stenosis and Percutaneous Coronary Intervention: a retrospective observational study.

作者信息

Joo Hyung Joon, Cho Sang-A, Cho Jae-Young, Park Jae Hyoung, Hong Soon Jun, Yu Cheol Woong, Lim Do-Sun

机构信息

Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, 126-1, 5ka, Anam-dong, Sungbuk-ku, Seoul, 136-705, Republic of Korea.

出版信息

BMC Cardiovasc Disord. 2017 Jan 31;17(1):45. doi: 10.1186/s12872-017-0476-7.

DOI:10.1186/s12872-017-0476-7

PMID:28137285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5282734/

Abstract

BACKGROUND

Arterial stiffness has been suggested as a valuable predictor of coronary artery stenosis (CAS). However, little data are available on aortic stiffness and CAS in patients who have previously undergone percutaneous coronary artery intervention (PCI). The aim of this study was to investigate the association of arterial stiffness to CAS in patients with a history of PCI and those without a history of PCI.

METHODS

We retrospectively studied 1093 consecutive patients who had undergone coronary angiography (CAG). Arterial stiffness was determined by brachial-ankle pulse wave velocity (baPWV) measured prior to CAG.

RESULTS

In patients without a history of PCI, baPWV significantly increased in patients with CAS compared to that in patients without CAS (p < 0.001). However, among patients with a history of PCI, there was no significant difference in baPWV. Multivariate logistic regression analysis demonstrated that baPWV was an independent risk predictor for CAS in patients without a history of PCI, but not in those with a history of PCI (OR 1.106, 95% CI 1.039-1.177, p = 0.002). In CAS patients without a history of PCI, increased baPWV was significantly associated with multiple cardiovascular risk factors, multivessel involvement, and anatomical severity.

CONCLUSIONS

Prediction of CAS by baPWV is significantly attenuated in patients with a history of PCI.

摘要

背景

动脉僵硬度已被认为是冠状动脉狭窄（CAS）的一个有价值的预测指标。然而，关于既往接受过经皮冠状动脉介入治疗（PCI）的患者的主动脉僵硬度和CAS的数据很少。本研究的目的是调查有PCI病史和无PCI病史的患者中动脉僵硬度与CAS的关联。

方法

我们回顾性研究了1093例连续接受冠状动脉造影（CAG）的患者。在CAG之前通过测量肱踝脉搏波速度（baPWV）来确定动脉僵硬度。

结果

在无PCI病史的患者中，与无CAS的患者相比，有CAS的患者baPWV显著升高（p < 0.001）。然而，在有PCI病史的患者中，baPWV没有显著差异。多因素逻辑回归分析表明，baPWV是无PCI病史患者CAS的独立风险预测指标，但在有PCI病史的患者中不是（OR 1.106，95% CI 1.039 - 1.177，p = 0.002）。在无PCI病史的CAS患者中，baPWV升高与多种心血管危险因素、多支血管受累和解剖严重程度显著相关。