Liu Yang, Ji Peihong, Lv Huilin, Qin Yong, Deng Linhong
Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
Int J Biol Macromol. 2017 May;98:550-556. doi: 10.1016/j.ijbiomac.2017.01.121. Epub 2017 Jan 27.
Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure comprising: (i) the chitosan solution was air-dried to form a chitosan (CS) film, (ii) using citric acid to generate the amide and carboxyl groups on the surface of CS, (iii) the CS with surface carboxyl groups was modified by grafting of gentamicin. After modification, this CS-GT film has excellent hydrophilicity and biocompatibility. It is very evident that the gentamicin grafting treatment significantly improves the antibacterial properties of the CS film. Our preliminary results suggest that this novel gentamicin modified chitosan film, which can be prepared in large quantities and at low cost, should have potential application in biomedical applications.
庆大霉素修饰的壳聚糖膜（CS-GT）采用三步法制备，包括：（i）将壳聚糖溶液风干形成壳聚糖（CS）膜，（ii）用柠檬酸在CS表面生成酰胺基和羧基，（iii）通过庆大霉素接枝对具有表面羧基的CS进行修饰。修饰后，这种CS-GT膜具有优异的亲水性和生物相容性。很明显，庆大霉素接枝处理显著提高了CS膜的抗菌性能。我们的初步结果表明，这种新型的庆大霉素修饰壳聚糖膜可大量低成本制备，在生物医学应用中应具有潜在应用价值。
