Qin Guangqiu, Wen Pingjing, Wang Yanwu, Zhang Lujuan, Liang Huili, Qin Huiyan, Tang Song, Zhao Peng
Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
Institute of Toxicology, Guangxi Center for Disease Prevention and Control, Nanning 530028, China.
Regul Toxicol Pharmacol. 2017 Apr;85:1-6. doi: 10.1016/j.yrtph.2017.01.005. Epub 2017 Jan 27.
Xylans are present naturally in various plants and have important uses in nutrition, food, novel material and biotechnology; however, to date, data regarding their systemic toxicity and safety evaluation is still limited. This study investigated the potential toxicity of xylan from sugarcane bagasse by a subchronic toxicity study in rats. A total of 80 male and female rats were fed with diets containing 10%, 5%, 2.5% and 0% (control) xylan for 90 days. A toxicological assessment was performed including mortality, body and organ weights, food consumption, blood biochemistry, hematology, urinalysis, gross necropsy and histopathological examinations. There were no signs of toxicity and treatment-related changes in rats treated with xylan. The no-observed-adverse-effect levels (NOAEL) of xylan were 9.0 g kg bw for males and 10.6 g kg bw for females of rats under this experimental condition, respectively.
木聚糖天然存在于各种植物中，在营养、食品、新型材料和生物技术领域具有重要用途；然而，迄今为止，关于其全身毒性和安全性评估的数据仍然有限。本研究通过对大鼠进行亚慢性毒性研究，调查了甘蔗渣木聚糖的潜在毒性。总共80只雄性和雌性大鼠被喂食含有10%、5%、2.5%和0%（对照）木聚糖的饲料，持续90天。进行了毒理学评估，包括死亡率、体重和器官重量、食物消耗量、血液生化、血液学、尿液分析、大体尸检和组织病理学检查。用木聚糖处理的大鼠没有毒性迹象和与处理相关的变化。在该实验条件下，大鼠木聚糖的未观察到有害作用水平（NOAEL）分别为雄性9.0 g kg bw和雌性10.6 g kg bw。
