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Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis.

作者信息

Gross Catharina C, Meyer Zu Hörste Gerd, Schulte-Mecklenbeck Andreas, Klotz Luisa, Meuth Sven G, Wiendl Heinz

机构信息

Department of Neurology, University Hospital Münster, Muenster D-48149, Germany

Department of Neurology, University Hospital Münster, Muenster D-48149, Germany.

出版信息

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E908-E909. doi: 10.1073/pnas.1619059114. Epub 2017 Jan 30.

DOI:10.1073/pnas.1619059114
PMID:28137888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5307479/
Abstract
摘要

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BMC Cancer. 2021 Feb 6;21(1):126. doi: 10.1186/s12885-021-07837-1.
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HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules.急性和慢性 HCV 感染患者的 HCV 特异性 CD4+ T 细胞显示出高水平的 TIGIT 和其他共抑制分子的表达。
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本文引用的文献

1
Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.基因变体rs763361调控多发性硬化症CD226基因的表达。
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E906-E907. doi: 10.1073/pnas.1618520114. Epub 2017 Jan 30.
2
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.白细胞介素-2受体调节可重建多发性硬化症中自然杀伤细胞介导的T细胞活性受损。
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2973-82. doi: 10.1073/pnas.1524924113. Epub 2016 May 9.
3
CD226 ligation protects against EAE by promoting IL-10 expression via regulation of CD4+ T cell differentiation.CD226 连接通过调节 CD4+ T 细胞分化促进白细胞介素-10 的表达，从而预防实验性自身免疫性脑脊髓炎。
Oncotarget. 2016 Apr 12;7(15):19251-64. doi: 10.18632/oncotarget.7834.
4
Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function.多发性硬化症相关的 CD226 遗传变异会损害调节性 T 细胞的功能。
Brain. 2015 Nov;138(Pt 11):3263-74. doi: 10.1093/brain/awv256. Epub 2015 Sep 10.
5
Systematic identification of trans eQTLs as putative drivers of known disease associations.系统识别跨表达数量性状基因座(trans eQTLs)作为已知疾病关联的潜在驱动因素。
Nat Genet. 2013 Oct;45(10):1238-1243. doi: 10.1038/ng.2756. Epub 2013 Sep 8.
6
The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.CD226/CD155 相互作用调节人类促炎（Th1/Th17）/抗炎（Th2）平衡。
J Immunol. 2013 Oct 1;191(7):3673-80. doi: 10.4049/jimmunol.1300945. Epub 2013 Aug 26.
7
A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.一个3'非翻译区变异与T细胞和自然杀伤T细胞中CD226表达受损相关，并与系统性红斑狼疮易感性相关。
Arthritis Rheum. 2010 Nov;62(11):3404-14. doi: 10.1002/art.27677.
8
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.自身免疫性疾病相关的 KIF5A、CD226 和 SH2B3 基因变异赋予多发性硬化症易感性。
Genes Immun. 2010 Jul;11(5):439-45. doi: 10.1038/gene.2010.30. Epub 2010 May 27.
9
Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.韦格纳肉芽肿病中CD226（DNAM-1）基因Gly307Ser多态性的新关联及德国患者多发性硬化症的确认
Genes Immun. 2009 Sep;10(6):591-5. doi: 10.1038/gene.2009.44. Epub 2009 Jun 18.
10
CD226 Gly307Ser association with multiple autoimmune diseases.CD226基因第307位密码子甘氨酸突变为丝氨酸与多种自身免疫性疾病的关联
Genes Immun. 2009 Jan;10(1):5-10. doi: 10.1038/gene.2008.82. Epub 2008 Oct 30.