Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.
作者信息
Liu Guiyou, Hu Yang, Jin Shuilin, Jiang Qinghua
机构信息
School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Department of Mathematics, School of Science, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
出版信息
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E906-E907. doi: 10.1073/pnas.1618520114. Epub 2017 Jan 30.
Abstract
摘要
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Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.基因变体rs763361调控多发性硬化症CD226基因的表达。
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Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis.回复刘等人：单倍型很重要：CD226基因多态性是多发性硬化症免疫调节受损的潜在触发因素。
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Autoimmune disease-associated CD226 gene variants are not involved in giant cell arteritis susceptibility in the Spanish population.自身免疫性疾病相关的 CD226 基因变异与西班牙人群的巨细胞动脉炎易感性无关。
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J Immunol. 2015 Aug 1;195(3):892-900. doi: 10.4049/jimmunol.1403046. Epub 2015 Jun 24.
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Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.白细胞介素-2受体调节可重建多发性硬化症中自然杀伤细胞介导的T细胞活性受损。
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Systematic identification of trans eQTLs as putative drivers of known disease associations.系统识别跨表达数量性状基因座(trans eQTLs)作为已知疾病关联的潜在驱动因素。
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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.跨基因表达数量性状位点（eQTLs）揭示了与复杂表型相关的独立遗传变异与中间基因相关，HLA 发挥主要作用。
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