• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.

作者信息

Liu Guiyou, Hu Yang, Jin Shuilin, Jiang Qinghua

机构信息

School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.

Department of Mathematics, School of Science, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.

出版信息

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E906-E907. doi: 10.1073/pnas.1618520114. Epub 2017 Jan 30.

DOI:10.1073/pnas.1618520114
PMID:28137889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5307472/
Abstract
摘要

相似文献

1
Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression.基因变体rs763361调控多发性硬化症CD226基因的表达。
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E906-E907. doi: 10.1073/pnas.1618520114. Epub 2017 Jan 30.
2
Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function.多发性硬化症相关的 CD226 遗传变异会损害调节性 T 细胞的功能。
Brain. 2015 Nov;138(Pt 11):3263-74. doi: 10.1093/brain/awv256. Epub 2015 Sep 10.
3
The CD226 gene in susceptibility of type 1 diabetes.CD226基因与1型糖尿病易感性
Tissue Antigens. 2009 Nov;74(5):417-9. doi: 10.1111/j.1399-0039.2009.01320.x. Epub 2009 Jul 15.
4
Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.细胞毒性T淋巴细胞相关抗原4（CTLA-4）、CD226、FAS基因多态性与类风湿关节炎易感性的关联：一项荟萃分析
Hum Immunol. 2015 Mar;76(2-3):83-9. doi: 10.1016/j.humimm.2015.01.023. Epub 2015 Jan 30.
5
CD226 Gly307Ser association with multiple autoimmune diseases: a meta-analysis.CD226 Gly307Ser 与多种自身免疫性疾病的关联：一项荟萃分析。
Hum Immunol. 2013 Feb;74(2):249-55. doi: 10.1016/j.humimm.2012.10.009. Epub 2012 Oct 13.
6
Association between CD226 polymorphism and soluble levels in rheumatoid arthritis: Relationship with clinical activity.类风湿关节炎中CD226基因多态性与可溶性水平的关联：与临床活动度的关系
Immunol Invest. 2018 Apr;47(3):264-278. doi: 10.1080/08820139.2018.1423570. Epub 2018 Jan 10.
7
Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis.回复刘等人：单倍型很重要：CD226基因多态性是多发性硬化症免疫调节受损的潜在触发因素。
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E908-E909. doi: 10.1073/pnas.1619059114. Epub 2017 Jan 30.
8
CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis.CD226（DNAM-1）与青少年特发性关节炎的易感性相关。
Ann Rheum Dis. 2015 Dec;74(12):2193-8. doi: 10.1136/annrheumdis-2013-205138. Epub 2014 Jul 23.
9
Autoimmune disease-associated CD226 gene variants are not involved in giant cell arteritis susceptibility in the Spanish population.自身免疫性疾病相关的 CD226 基因变异与西班牙人群的巨细胞动脉炎易感性无关。
Clin Exp Rheumatol. 2012 Jan-Feb;30(1 Suppl 70):S29-33. Epub 2012 May 10.
10
Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis.系统性硬化症患者CD8⁺T细胞上CD226表达增加与细胞因子产生上调及内皮细胞损伤相关。
J Immunol. 2015 Aug 1;195(3):892-900. doi: 10.4049/jimmunol.1403046. Epub 2015 Jun 24.

引用本文的文献

1
Natural killer cells in multiple sclerosis: foe or friends?多发性硬化症中的自然杀伤细胞：敌还是友？
Front Cell Neurosci. 2025 Apr 4;19:1500770. doi: 10.3389/fncel.2025.1500770. eCollection 2025.
2
The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental Connections.多发性硬化症的多基因性质：基因变异、免疫调节及与环境的关联
Endocr Metab Immune Disord Drug Targets. 2024 Dec 31. doi: 10.2174/0118715303325979241206115417.
3
Revisiting T-cell adhesion molecules as potential targets for cancer immunotherapy: CD226 and CD2.重新审视 T 细胞黏附分子作为癌症免疫治疗的潜在靶点：CD226 和 CD2。
Exp Mol Med. 2024 Oct;56(10):2113-2126. doi: 10.1038/s12276-024-01317-9. Epub 2024 Oct 1.
4
Impact of the Multiple Sclerosis-Associated Genetic Variant Gly307Ser on Human CD8 T-Cell Functions.多发性硬化症相关遗传变异 Gly307Ser 对人 CD8 T 细胞功能的影响。
Neurol Neuroimmunol Neuroinflamm. 2024 Nov;11(6):e200306. doi: 10.1212/NXI.0000000000200306. Epub 2024 Sep 4.
5
ADH-Enhancer: an attention-based deep hybrid framework for enhancer identification and strength prediction.ADH-Enhancer：一种基于注意力的深度混合框架，用于增强子识别和强度预测。
Brief Bioinform. 2024 Jan 22;25(2). doi: 10.1093/bib/bbae030.
6
The association between disability progression, relapses, and treatment in early relapse onset MS: an observational, multi-centre, longitudinal cohort study.早期复发发作 MS 中残疾进展、复发和治疗之间的关联：一项观察性、多中心、纵向队列研究。
Sci Rep. 2023 Jul 18;13(1):11584. doi: 10.1038/s41598-023-38415-z.
7
The Negative Impact of Triptolide on the Immune Function of Human Natural Killer Cells.雷公藤甲素对人自然杀伤细胞免疫功能的负面影响。
Pharmaceuticals (Basel). 2023 Mar 18;16(3):458. doi: 10.3390/ph16030458.
8
Association of GAB2 with Quality of Life and Negative Emotions in Patients with Gastric Cancer after Postoperative Comprehensive Care.术后综合护理后胃癌患者中GAB2与生活质量及负面情绪的关联
Evid Based Complement Alternat Med. 2022 Jul 31;2022:1732214. doi: 10.1155/2022/1732214. eCollection 2022.
9
Emergence of the CD226 Axis in Cancer Immunotherapy.CD226 轴在癌症免疫治疗中的出现。
Front Immunol. 2022 Jun 24;13:914406. doi: 10.3389/fimmu.2022.914406. eCollection 2022.
10
Natural Killer Cells in Multiple Sclerosis: Entering the Stage.自然杀伤细胞在多发性硬化症中的作用：崭露头角。
Front Immunol. 2022 Apr 6;13:869447. doi: 10.3389/fimmu.2022.869447. eCollection 2022.

本文引用的文献

1
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.白细胞介素-2受体调节可重建多发性硬化症中自然杀伤细胞介导的T细胞活性受损。
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2973-82. doi: 10.1073/pnas.1524924113. Epub 2016 May 9.
2
Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.人类基因组学。基因型-组织表达（GTEx）试点分析：人类多组织基因调控
Science. 2015 May 8;348(6235):648-60. doi: 10.1126/science.1262110. Epub 2015 May 7.
3
Genetic variability in the regulation of gene expression in ten regions of the human brain.人类大脑十个区域中基因表达调控的遗传变异性。
Nat Neurosci. 2014 Oct;17(10):1418-1428. doi: 10.1038/nn.3801. Epub 2014 Aug 31.
4
Transcriptome and genome sequencing uncovers functional variation in humans.转录组和基因组测序揭示了人类功能变异。
Nature. 2013 Sep 26;501(7468):506-11. doi: 10.1038/nature12531. Epub 2013 Sep 15.
5
Systematic identification of trans eQTLs as putative drivers of known disease associations.系统识别跨表达数量性状基因座(trans eQTLs)作为已知疾病关联的潜在驱动因素。
Nat Genet. 2013 Oct;45(10):1238-1243. doi: 10.1038/ng.2756. Epub 2013 Sep 8.
6
Mapping cis- and trans-regulatory effects across multiple tissues in twins.在双胞胎的多个组织中映射顺式和反式调控作用。
Nat Genet. 2012 Oct;44(10):1084-9. doi: 10.1038/ng.2394. Epub 2012 Sep 2.
7
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.跨基因表达数量性状位点（eQTLs）揭示了与复杂表型相关的独立遗传变异与中间基因相关，HLA 发挥主要作用。
PLoS Genet. 2011 Aug;7(8):e1002197. doi: 10.1371/journal.pgen.1002197. Epub 2011 Aug 4.
8
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort.对病态肥胖队列的胃、肝和脂肪组织基因表达的遗传学调查。
Genome Res. 2011 Jul;21(7):1008-16. doi: 10.1101/gr.112821.110. Epub 2011 May 20.
9
Tissue-specific genetic control of splicing: implications for the study of complex traits.剪接的组织特异性遗传控制：对复杂性状研究的启示。
PLoS Biol. 2008 Dec 23;6(12):e1. doi: 10.1371/journal.pbio.1000001.
10
CD226 Gly307Ser association with multiple autoimmune diseases.CD226基因第307位密码子甘氨酸突变为丝氨酸与多种自身免疫性疾病的关联
Genes Immun. 2009 Jan;10(1):5-10. doi: 10.1038/gene.2008.82. Epub 2008 Oct 30.