穴居人与法拉利的寓言：蛋白质合成与RNA世界
The parable of the caveman and the Ferrari: protein synthesis and the RNA world.
作者信息
Noller Harry F
机构信息
Center for Molecular Biology of RNA, University of California at Santa Cruz, Santa Cruz, CA 95064, USA
Department of Molecular, Cell and Developmental Biology, University of California at Santa Cruz, Santa Cruz, CA 95064, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). doi: 10.1098/rstb.2016.0187.
Abstract
The basic steps of protein synthesis are carried out by the ribosome, a very large and complex ribonucleoprotein particle. In keeping with its proposed emergence from an RNA world, all three of its core mechanisms-aminoacyl-tRNA selection, catalysis of peptide bond formation and coupled translocation of mRNA and tRNA-are embodied in the properties of ribosomal RNA, while its proteins play a supportive role.This article is part of the themed issue 'Perspectives on the ribosome'.
摘要
蛋白质合成的基本步骤由核糖体执行，核糖体是一种非常大且复杂的核糖核蛋白颗粒。与其从RNA世界起源的假说相一致，核糖体的所有三个核心机制——氨酰tRNA选择、肽键形成催化以及mRNA和tRNA的偶联转位——都体现在核糖体RNA的特性中，而其蛋白质则起辅助作用。本文是主题为“核糖体的视角”特刊的一部分。
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