Tadokoro Shigenori, Nonomura Naho, Kanahara Nobuhisa, Hashimoto Kenji, Iyo Masaomi
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
Health Administration Center, Muroran Institute of Technology, Hokkaido, Japan.
Clin Psychopharmacol Neurosci. 2017 Feb 28;15(1):79-81. doi: 10.9758/cpn.2017.15.1.79.
Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical antipsychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46-year-old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic patients with DSP, and may be an effective treatment of DSP.
多巴胺超敏性精神病（DSP）是精神分裂症患者长期使用抗精神病药物治疗引起的复发性精神病的一种急性加重类型。尽管DSP给临床医生带来极大困扰，但尚未确立有效的治疗方法。基于临床研究和我们的动物研究，我们推测非典型抗精神病药物阿立哌唑可能会减轻复发性精神病发作的加重情况。我们报告了一例患有DSP的46岁女性精神分裂症患者的病例。在该病例中，高剂量阿立哌唑持续治疗逐渐减轻了她复发性精神病发作的严重程度。总之，阿立哌唑持续治疗可能会减轻患有DSP的精神分裂症患者复发性精神病发作的加重情况，可能是治疗DSP的一种有效方法。
