Zhao Jin, Guo Zhong, Wang Qiang, Si Tianbin, Pei Shuyan, Wang Chenjing, Qu Hongmei, Zhong Jianbin, Ma Ying, Nie Cong, Zhang Dan
Medical College of Northwest University for Nationalities, Lanzhou, 730030 People's Republic of China.
No.1 Hospital of Longnan City, Longnan, 746000 People's Republic of China.
Infect Agent Cancer. 2017 Jan 25;12:8. doi: 10.1186/s13027-017-0116-y. eCollection 2017.
The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.
Between 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes.
Compared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38.60%, 74.60%, 87.50% and 89.05%, 0.001) and the positivity is also higher in SCC compared to CINI ( 0.01). The most frequently detected genotypes were HPV16 in cervicitis, HPV16, 58 and 52 in CINI and CIN II/III, and HPV16, 58 and 18 in SCC groups. HPV16 positivity in cervicitis, CINI, CIN II/III, and SCC patients were 45.46%, 46.81%, 60.32% and 78.69%, respectively. Compared to cervicitis and CINI, the odds ratios (OR) for SCC in HPV16 positive patients were 2.96 (95% confidence interval [CI]: 1.09-8.00, 0.05) and 4.20 (95% confidence interval [CI]: 2.05-8.61, 0.001), respectively. In addition, the multiple infections in cervicitis, CINI, CINII/III and SCC group are 9.09%, 27.66%, 26.98% and 25.41% and HPV16 + 58 was the most common combinations.
These findings highlight the key role of HPV16, 58, 52 and 18 in the development of CIN and SCC in Longnan women and a fully aware of regional differences in HPV genotype distribution are tasks for cervical cancer control and prevention.
陇南宫颈癌死亡率高达39/1000万，居全国首位。
2012年至2016年期间，收集了329份宫颈炎、宫颈上皮内瘤变1至3级（CINI至III级）和浸润性鳞状细胞癌（SCC）样本。使用经过验证的试剂盒检测23种不同HPV亚型的HPV基因型。
与宫颈炎相比，CINI、CIN II/III和SCC中的HPV阳性率显著更高（分别为38.60%、74.60%、87.50%和89.05%，P<0.001），且SCC中的阳性率也高于CINI（P<0.01）。最常检测到的基因型在宫颈炎中为HPV16，在CINI和CIN II/III中为HPV16、58和52，在SCC组中为HPV16、58和18。宫颈炎、CINI、CIN II/III和SCC患者中的HPV16阳性率分别为45.46%、46.81%、60.32%和78.69%。与宫颈炎和CINI相比，HPV16阳性患者发生SCC的比值比（OR）分别为2.96（95%置信区间[CI]：1.09 - 8.00，P<0.05）和4.20（95%置信区间[CI]：2.05 - 8.61，P<0.001）。此外，宫颈炎、CINI、CINII/III和SCC组中的多重感染率分别为9.09%、27.66%、26.98%和25.41%，HPV16 + 58是最常见的组合。
这些发现突出了HPV16、58、52和18在陇南女性CIN和SCC发生中的关键作用，充分认识HPV基因型分布的区域差异是宫颈癌防控的任务。
