日本女性人乳头瘤病毒联合检测结果与宫颈上皮内瘤变的相关性
Correlation between Human Papillomavirus Codetection Profiles and Cervical Intraepithelial Neoplasia in Japanese Women.
作者信息
Okayama Kaori, Kimura Hirokazu, Teruya Koji, Ishii Yasuyoshi, Fujita Kiyotaka, Fujii Masahiko, Oda Mizue, Sasagawa Toshiyuki, Okodo Mitsuaki
机构信息
Department of Medical Technology, Faculty of Health Sciences, Gunma Paz University, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.
Department of Health and Welfare, Faculty of Health Sciences, Kyorin University, 5-4-1 Shimorenjaku, Mitaka-shi, Tokyo 181-8621, Japan.
出版信息
Microorganisms. 2020 Nov 25;8(12):1863. doi: 10.3390/microorganisms8121863.
Human papillomavirus (HPV) infection is thought to be strongly associated with the precarcinomatous state cervical intraepithelial neoplasia (CIN) and cervical carcinoma. To accurately assess the correlation between HPV detection profiles and CIN, the uniplex E6/E7 polymerase chain reaction (PCR) method was used. We detected HPV (37 genotypes) in 267 CIN cases. The detection of a single high-risk HPV genotype occurred in 69.7% of CIN1 and worse than CIN1 (CIN1+) cases whereas other types were detected in 11.6% of cases. Codetection of high-risk HPV genotypes occurred in 4.9% of CIN1+ cases. The high-risk genotype HPV16 was the most frequently detected genotype in CIN1+ lesions; the genotype HPV34 (not a high-risk type) was detected in some CIN3 cases. Furthermore, HPV codetection may not be associated with CIN grades. These results suggest that various HPV genotypes are associated with CIN across all analyzed cases.
人乳头瘤病毒（HPV）感染被认为与癌前状态宫颈上皮内瘤变（CIN）和宫颈癌密切相关。为准确评估HPV检测谱与CIN之间的相关性，采用了单重E6/E7聚合酶链反应（PCR）方法。我们在267例CIN病例中检测了HPV（37种基因型）。在69.7%的CIN1及比CIN1更严重（CIN1+）的病例中检测到单一高危HPV基因型，而在11.6%的病例中检测到其他类型。在4.9%的CIN1+病例中检测到高危HPV基因型的共同感染。高危基因型HPV16是CIN1+病变中最常检测到的基因型；在一些CIN3病例中检测到HPV34基因型（非高危型）。此外，HPV共同感染可能与CIN分级无关。这些结果表明，在所有分析病例中，各种HPV基因型均与CIN相关。
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