Lianos Georgios D, Hasemaki Natasha, Vaggelis Georgios, Karampa Anastasia, Anastasiadi Zoi, Lianou Aikaterini, Papanikolaou Sarantis, Floras Grigorios, Bali Christina D, Lekkas Epameinondas, Katsios Christos, Mitsis Michail
Department of Surgery, Ioannina University Hospital & University of Ioannina, Ioannina, Greece; ; Department of Surgery, General Hospital of Preveza, Preveza, Greece.
Department of Surgery, General Hospital of Preveza, Preveza, Greece.
Transl Gastroenterol Hepatol. 2016 Dec 23;1:91. doi: 10.21037/tgh.2016.12.02. eCollection 2016.
Complete (R0) resection and regional lymph nodes (LNs) dissection represent undoubtedly the basic surgical tools for patients with gastric cancer. It is reported that the LN metastasis rate in patients with early gastric cancer (EGC) is approximately 15-20%. Therefore, the innovative clinical application of sentinel node navigation surgery (SNNS) for EGC might be able to prevent unnecessary LN dissection as well as to reduce significantly the volume of gastric resection. Recent evidence suggests that double tracer methods appear superior compared to single tracer techniques. However, the researchers' interest is now focused on the identification of new LN detection methods utilizing sophisticated technology such as infrared ray endoscopy, fluorescence imaging and near-infrared technology. Despite its notable limitations, hematoxylin-eosin is still considered the mainstay staining for assessing the metastatic status of LNs. In this review, we summarize the current evidences and we provide the latest scientific information assessing safety, efficacy and potential limitations of the innovative sentinel node (SN) navigation technique for gastric cancer. We try also to provide a "view" towards a future potential application of personalized minimally invasive surgery in gastric cancer field.
完整（R0）切除及区域淋巴结（LN）清扫无疑是胃癌患者的基本手术方式。据报道，早期胃癌（EGC）患者的LN转移率约为15%-20%。因此，EGC的前哨淋巴结导航手术（SNNS）的创新性临床应用或许能够避免不必要的LN清扫，并显著减少胃切除的范围。近期证据表明，与单示踪技术相比，双示踪方法似乎更具优势。然而，研究人员目前的兴趣集中在利用诸如红外线内镜、荧光成像和近红外技术等先进技术来识别新的LN检测方法。尽管苏木精-伊红染色存在明显局限性，但它仍被视为评估LN转移状态的主要染色方法。在本综述中，我们总结了当前证据，并提供了评估胃癌创新性前哨淋巴结（SN）导航技术的安全性、有效性及潜在局限性的最新科学信息。我们还尝试展望个性化微创手术在胃癌领域未来的潜在应用。
