中国精神分裂症患者电休克治疗后的记忆损害：随机对照试验的荟萃分析
Memory Impairment Following Electroconvulsive Therapy in Chinese Patients with Schizophrenia: Meta-Analysis of Randomized Controlled Trials.
作者信息
Zheng Wei, Tong Guo, Ungvari Gabor S, Ng Chee H, Chiu Helen F K, Xiang Ying-Qiang, Cao Xiao-Lan, Liu Zheng-Rong, Meng Li-Rong, Gazdag Gábor, Xiang Yu-Tao
机构信息
Resident Psychiatrist, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
Resident Psychiatrist, The National Clinical Research Center for Mental Disorders and Beijing Anding Hospital, Capital Medical University, Beijing, China.
出版信息
Perspect Psychiatr Care. 2018 Apr;54(2):107-114. doi: 10.1111/ppc.12206. Epub 2017 Jan 30.
PURPOSE
To evaluate memory impairment associated with electroconvulsive therapy (ECT)-antipsychotic (AP) combination in comparison to AP monotherapy in schizophrenia.
DESIGN AND METHODS
A systematic literature search of randomized controlled trial (RCTs) was performed.
FINDINGS
Eleven RCTs that compared ECT-AP combination (n = 508) with AP monotherapy (n = 510) were analyzed. ECT-AP combination was associated with greater impairment than AP monotherapy in (1) endpoint memory quotient (MQ) of the Wechsler Memory Scale (WMS)-Revised at the end of the ECT course; and (2) picture recall, counting, recognition, and associative learning of the WMS. However, no group difference was found in MQ at 1 and 2 weeks post-ECT.
PRACTICE IMPLICATIONS
The ECT-AP combination was associated with greater transient memory impairment compared to AP monotherapy.
目的
评估与精神分裂症患者使用抗精神病药物（AP）单药治疗相比，电休克治疗（ECT）联合抗精神病药物治疗相关的记忆损害情况。
设计与方法
对随机对照试验（RCT）进行系统的文献检索。
结果
分析了11项比较ECT联合AP治疗（n = 508）与AP单药治疗（n = 510）的随机对照试验。ECT联合AP治疗与AP单药治疗相比，在以下方面存在更严重的损害：（1）ECT疗程结束时韦氏记忆量表（WMS）修订版的终点记忆商数（MQ）；（2）WMS的图片回忆、计数、识别和联想学习。然而，ECT后1周和2周时，两组在MQ方面未发现差异。
实践意义
与AP单药治疗相比，ECT联合AP治疗会导致更严重的短暂性记忆损害。
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