Gliwińska Aleksandra, Czubilińska-Łada Justyna, Więckiewicz Gniewko, Świętochowska Elżbieta, Badeński Andrzej, Dworak Marta, Szczepańska Maria
Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Neonatal Intensive Care, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Brain Sci. 2023 Jan 18;13(2):163. doi: 10.3390/brainsci13020163.
Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are growth factors with trophic effects on neurons. BDNF is the most widely distributed neurotrophin in the central nervous system (CNS) and is highly expressed in the prefrontal cortex (PFC) and hippocampus. Its distribution outside the CNS has also been demonstrated, but most studies have focused on its effects in neuropsychiatric disorders. Despite the advances in medicine in recent decades, neurological and psychiatric diseases are still characterized by high drug resistance. This review focuses on the use of BDNF in the developmental assessment, treatment monitoring, and pharmacotherapy of selected diseases, with a particular emphasis on epilepsy, depression, anorexia, obesity, schizophrenia, and Alzheimer's disease. The limitations of using a molecule with such a wide distribution range and inconsistent method of determination are also highlighted.
脑源性神经营养因子（BDNF）属于神经营养因子家族，这些神经营养因子是对神经元具有营养作用的生长因子。BDNF是中枢神经系统（CNS）中分布最广泛的神经营养因子，在前额叶皮质（PFC）和海马体中高度表达。其在CNS外的分布也已得到证实，但大多数研究都集中在其在神经精神疾病中的作用。尽管近几十年来医学取得了进步，但神经和精神疾病仍然具有高耐药性的特点。本综述重点关注BDNF在特定疾病的发育评估、治疗监测和药物治疗中的应用，尤其侧重于癫痫、抑郁症、厌食症、肥胖症、精神分裂症和阿尔茨海默病。还强调了使用具有如此广泛分布范围和不一致测定方法的分子的局限性。
