Doozandeh Azadeh, Yazdani Shahin, Ansari Shabnam, Pakravan Mohammad, Motevasseli Tahmineh, Hosseini Bagher, Yasseri Mehdi
Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Acta Ophthalmol. 2017 Nov;95(7):e575-e581. doi: 10.1111/aos.13357. Epub 2017 Jan 31.
To investigate biomechanical and ultrastructural corneal parameters and ocular biometrics in the affected eyes of patients with unilateral primary congenital glaucoma (PCG) as compared to unaffected fellow eyes and age-matched healthy controls.
A total of 12 patients with treated unilateral PCG and 10 normal subjects were evaluated. LENSTAR was performed to determine biometric parameters; the ocular response analyser was employed to determine biomechanical properties and slit-scanning confocal microscopy was used for evaluation of corneal ultrastucture.
Axial length was significantly higher and mean keratometry in affected eyes was significantly flatter in affected eyes as compared to fellow eyes and normal controls (p < 0.05), and a negative correlation was present between axial length and mean keratometry (p < 0.05). Mean aqueous depth and anterior chamber depth were increased in affected eyes as compared to fellow eyes and normal controls (p < 0.05). There was no significant difference in central corneal thickness (CCT) among affected eyes, fellow eyes and normal controls. Corneal hysteresis (CH) was significantly reduced in affected eyes (p < 0.05) and corneal resistance factor (CRF) was also reduced in the affected eyes as compared to fellow eyes and normal controls, although not statistically significant. Mean endothelial cell density was reduced in the affected eyes compared to fellow eyes and normal controls (p < 0.05).
Corneal biometrics, biomechanical parameters and ultrastructural features are altered in eyes affected with PCG despite clinically normal and clear corneas. These findings should be considered in the preoperative assessment of intraocular or corneal surgery in these patients.
研究单侧原发性先天性青光眼（PCG）患者患眼的生物力学和超微结构角膜参数以及眼部生物特征，并与未受影响的对侧眼和年龄匹配的健康对照进行比较。
共评估了12例接受治疗的单侧PCG患者和10名正常受试者。使用LENSTAR测量生物特征参数；采用眼反应分析仪测定生物力学特性，并使用裂隙扫描共聚焦显微镜评估角膜超微结构。
与对侧眼和正常对照组相比，患眼的眼轴长度显著更长，平均角膜曲率显著更平（p < 0.05），且眼轴长度与平均角膜曲率之间存在负相关（p < 0.05）。与对侧眼和正常对照组相比，患眼的平均房水深度和前房深度增加（p < 0.05）。患眼、对侧眼和正常对照组之间的中央角膜厚度（CCT）无显著差异。患眼角膜滞后（CH）显著降低（p < 0.05），与对侧眼和正常对照组相比，患眼角膜阻力因子（CRF）也降低，尽管差异无统计学意义。与对侧眼和正常对照组相比，患眼的平均内皮细胞密度降低（p < 0.05）。
尽管角膜在临床上正常且清晰，但PCG患眼的角膜生物特征、生物力学参数和超微结构特征仍发生改变。在对这些患者进行眼内或角膜手术的术前评估时应考虑这些发现。
