Department of Ophthalmology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Cornea. 2011 Sep;30(9):983-6. doi: 10.1097/ICO.0b013e318213a80d.
To assess the corneal biomechanical properties of patients with pseudoexfoliation syndrome (PEX syndrome).
Fifty-two eyes of 52 patients (27 unilateral and 25 bilateral) and 42 eyes of 42 age-matched control subjects were enrolled in the study. Metrics of corneal biomechanical properties, including corneal hysteresis (CH) and corneal resistance factor (CRF), were measured with the ocular response analyzer (ORA). The ORA also determined the values of Goldmann-correlated intraocular pressure and corneal-compensated intraocular pressure. Central corneal thickness (CCT) was measured by the ORA integrated handheld ultrasonic pachymeter. The values recorded by the ORA were compared between eyes with PEX syndrome and those without PEX syndrome. Eyes with unilateral PEX syndrome and fellow eyes without PEX syndrome were also compared.
The mean CH and CRF of all eyes with PEX syndrome were significantly lower than those of control eyes (P < 0.05). Neither corneal-compensated intraocular pressure nor Goldmann-correlated intraocular pressure showed a statistically significant difference in both the groups. Mean CCT values also did not show significant difference. Comparison of the unilateral eyes with PEX syndrome with the apparently normal fellow eyes revealed no significant difference between the mean CCT, mean CH, and mean CRF values (P > 0.05). However, the mean corneal-compensated intraocular pressure and Goldmann-correlated intraocular pressure were relatively higher in the PEX syndrome eye (P < 0.05). There was no significant difference between the mean CCT values of these groups (P > 0.05).
The CH and CRF decrease in both unilateral and bilateral PEX syndrome suggested that PEX syndrome has a weakening effect on corneal biomechanical properties. Moreover, in subjects with clinically unilateral PEX syndrome, these properties were closer to eyes with PEX syndrome than to normal control eyes.
评估假性剥脱综合征（PEX 综合征）患者的角膜生物力学特性。
本研究纳入了 52 只眼（27 只单眼和 25 只双眼）的 52 例 PEX 综合征患者和 42 只眼的 42 例年龄匹配的对照者。使用眼反应分析仪（ORA）测量角膜生物力学特性的各项指标，包括角膜滞后量（CH）和角膜阻力因子（CRF）。ORA 还确定了 Goldmann 相关眼压和角膜补偿眼压的值。使用 ORA 集成的手持式超声角膜测厚仪测量中央角膜厚度（CCT）。比较 PEX 综合征眼与无 PEX 综合征眼之间的 ORA 记录值。还比较了单侧 PEX 综合征眼和无 PEX 综合征的对侧眼。
所有 PEX 综合征眼的平均 CH 和 CRF 均明显低于对照组（P < 0.05）。两组的角膜补偿眼压和 Goldmann 相关眼压均无统计学差异。平均 CCT 值也无显著差异。单侧 PEX 综合征眼与明显正常的对侧眼比较，平均 CCT、平均 CH 和平均 CRF 值无显著差异（P > 0.05）。然而，PEX 综合征眼中的平均角膜补偿眼压和 Goldmann 相关眼压相对较高（P < 0.05）。这些组的平均 CCT 值无显著差异（P > 0.05）。
单侧和双侧 PEX 综合征的 CH 和 CRF 降低表明 PEX 综合征对角膜生物力学特性具有削弱作用。此外，在患有临床单侧 PEX 综合征的患者中，这些特性更接近 PEX 综合征眼，而不是正常对照眼。
