长链非编码 RNA 调控 ROR1-HER3 和 Hippo 信号通路在转移中的作用。
Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.
机构信息
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
出版信息
Nat Cell Biol. 2017 Jan 31;19(2):81-83. doi: 10.1038/ncb3467.
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.
长非编码 RNA（lncRNA）在癌症进展中的作用越来越受到重视。以前未被描述的 lncRNA MAYA 通过桥接 ROR1-HER3 和 Hippo-YAP 通路，现在被证明可以促进骨转移。ROR1 诱导的神经调节素诱导的 HER3 磷酸化募集包含 MAYA 的蛋白复合物，使 Hippo/MST1 甲基化，并激活 YAP 靶基因，这些基因对骨转移至关重要。
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