Molho M, Katz I, Lutzky A, Lotan G, Benzaray S
Clinical Respiratory Physiology Laboratory, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel.
Respiration. 1989;55(3):169-75. doi: 10.1159/000195728.
Maximal expiratory flow-volume curves were recorded in 85 healthy subjects, aged from 18 to 78 years. The maximal expiratory flow was measured at 75, 50 and 25% of the vital capacity (VmaxVC), at 60 and 40% of the total lung capacity (VmaxTLC), and at the functional residual capacity level (VmaxFRC). The latter was adjusted for the lung volume at which it was measured. The new parameter was named specific VmaxFRC (SVmaxFRC) and expressed in s-1. Normal values and prediction formulas based on height, weight, age and sex were established. It was found that: (1) adjustment for lung volume narrowed the interindividual variability of SVmaxFRC from 47 to 37%; (2) did not diminish the influence of age (p less than 0.001); (3) erased the influence of height and VC; (4) reduced the correlation with FEV1 (p less than 0.05), and (5) unveiled a borderline correlation with specific conductance (p less than 0.05).
对85名年龄在18至78岁的健康受试者记录了最大呼气流量-容积曲线。在肺活量的75%、50%和25%（VmaxVC）、肺总量的60%和40%（VmaxTLC）以及功能残气量水平（VmaxFRC）处测量最大呼气流量。后者针对其测量时的肺容积进行了校正。新参数被命名为比VmaxFRC（SVmaxFRC），并以s-1表示。建立了基于身高、体重、年龄和性别的正常值及预测公式。结果发现：（1）对肺容积进行校正后，SVmaxFRC的个体间变异性从47%缩小至37%；（2）并未减弱年龄的影响（p<0.001）；（3）消除了身高和肺活量的影响；（4）降低了与第一秒用力呼气容积（FEV1）的相关性（p<0.05），以及（5）揭示了与比传导率的临界相关性（p<0.05）。
