LRP5基因（rs556442）的多态性与伊朗儿童较高的甘油三酯水平相关。

Polymorphism in LRP5 (rs556442) is associated with higher TG levels in Iranian children.

作者信息

Montazeri-Najafabady Nima, Dabbaghmanesh Mohammad Hossein, Omrani Gholamhossein Ranjbar, Saki Forough, Bakhshayeshkaram Marzieh

机构信息

a Shiraz Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences , Shiraz , Iran.

b Health Policy Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.

出版信息

Ann Hum Biol. 2017 Jun;44(4):373-378. doi: 10.1080/03014460.2017.1287953. Epub 2017 Apr 4.

DOI:10.1080/03014460.2017.1287953

PMID:28139941

Abstract

BACKGROUND

Wnt signalling/LRP5 is involved in adipogenesis by down-regulating adipogenic transcription factors. Therefore polymorphisms in components of this pathway may lead to metabolic disorders.

AIM

This study tested the impact of LRP5 polymorphism on lipid profile in Iranian children.

METHODS

The study population was comprised of 9-18 year old children (125 boys, 137 girls). Total cholesterol (TC), High Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Non-HDL cholesterol and Triglyceride (TG) levels were checked. Body composition was measured by the Hologic system DXA. PCR/restriction fragment length polymorphism (RFLP) was done for LRP5 (rs556442) genotyping. Multiple association analyses for TG level and genotype frequencies were assessed using logistic regression analysis, with adjustment for age, sex, BMI and puberty.

RESULTS

The results revealed that LRP5 (rs556442) had a significant influence on TG levels in unadjusted analysis and when adjusted for interacting factors. Higher TG levels were observed in AA/AG genotype of rs566442 in comparison to GG genotype (OR = 2.028, 95% CI = 0.997-4.127, p = 0.049).

CONCLUSION

It is concluded that allele A has an important impact on increasing TG level in LRP5 in the studied population.

摘要

背景

Wnt信号通路/LRP5通过下调脂肪生成转录因子参与脂肪生成。因此，该通路成分的多态性可能导致代谢紊乱。

目的

本研究检测LRP5基因多态性对伊朗儿童血脂谱的影响。

方法

研究人群为9至18岁儿童（125名男孩，137名女孩）。检测总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、非HDL胆固醇和甘油三酯（TG）水平。采用Hologic系统双能X线吸收仪测量身体成分。对LRP5（rs556442）进行基因分型，采用聚合酶链反应/限制性片段长度多态性（RFLP）方法。使用逻辑回归分析评估TG水平与基因型频率的多重关联分析，并对年龄、性别、BMI和青春期进行校正。