Póvoa Ana, Severo Milton, Xavier Pedro, Matias Alexandra, Blickstein Isaac
a Department of Obstetrics and Gynecology, Unit of Reproductive Medicine , Hospitalar Center São João , Porto , Portugal.
b Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto , Porto , Portugal.
J Matern Fetal Neonatal Med. 2018 Feb;31(4):453-456. doi: 10.1080/14767058.2017.1287896. Epub 2017 Feb 21.
To assess the predictive value for clinical pregnancy outcome of β-hCG level at 13 d after embryo transfer.
Retrospective study of IVF clinical pregnancies diagnosed at 6 weeks. We calculated the value of β-hCG level at 13 d after embryo transfer to predict live births.
We analyzed 177 IVF cycles between 2009 and 2014 (50 singleton births, 50 twin births, 27 sets with a vanishing twin, 43 first trimester singleton pregnancy loss and seven first trimester total twin pregnancy loss). Singleton pregnancies with a β-hCG concentration <85 mIU/mL had an 89% risk of having a first trimester loss whereas a concentration >386 mU/mL had a 91% chance of a live birth. Twin pregnancies with a concentration <207 mIU/mL had only a 33% chance of delivering twins and a 55% risk of having a vanishing twin; whereas a level >768 mIU/mL was associated with a 81% chance of live twin birth and a low risk (19%) of having a vanishing twin. Age, type and duration of infertility, body mass index (BMI) and number of fertilized oocytes did not affect these calculations.
β-hCG level at 13 d after embryo transfer might predict outcomes in clinical singleton and twin pregnancies following IVF.
评估胚胎移植后13天β-hCG水平对临床妊娠结局的预测价值。
对6周时诊断为体外受精（IVF）临床妊娠的病例进行回顾性研究。我们计算胚胎移植后13天β-hCG水平的值以预测活产情况。
我们分析了2009年至2014年间的177个IVF周期（50例单胎分娩、50例双胎分娩、27例有消失双胎的情况、43例孕早期单胎妊娠丢失以及7例孕早期双胎妊娠全部丢失）。β-hCG浓度<85 mIU/mL的单胎妊娠孕早期丢失风险为89%，而浓度>386 mU/mL时活产几率为91%。β-hCG浓度<207 mIU/mL的双胎妊娠分娩双胎的几率仅为33%，有消失双胎的风险为55%；而浓度>768 mIU/mL时双胎活产几率为81%，有消失双胎的风险较低（19%）。年龄、不孕类型和持续时间、体重指数（BMI）以及受精卵子数量均不影响这些计算结果。
胚胎移植后13天的β-hCG水平可能预测IVF后临床单胎和双胎妊娠的结局。
