Póvoa Ana, Xavier Pedro, Matias Alexandra, Blickstein Isaac
Department of Obstetrics and Gynecology, Unit of Reproductive Medicine, Hospitalar Center São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
Department of Gynecology and Obstetrics, Faculty of Medicine, University of Porto/Hospitalar Center S. João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
J Perinat Med. 2018 Oct 25;46(8):853-856. doi: 10.1515/jpm-2017-0132.
Objective To compare levels of β-hCG and estradiol collected during the first trimester in singleton and twin pregnancies following assisted reproduction technologies (ART). Methods We prospectively evaluated 50 singleton and 47 dichorionic twin pregnancies that eventually ended in live births. Patients were recruited from a single ART center with standard treatment protocols followed by fresh embryo transfers. Hormone measurements were performed within a narrow gestational age range and analyzed in a single laboratory thus minimizing inter- and intra-assay variability. We measured serum β-hCG at 13 days after embryo transfer as well as samples of β-hCG and estradiol at 8-9 weeks+6 days. Results No significant differences existed between singletons and twins in respect to demographic and cycle characteristics. β-hCG and estradiol were all significantly higher in twins (P<0.05). Conclusion The data confirms the higher levels of β-hCG and estradiol in twins, pointing to the potential role of these placental hormones in early support of a twin pregnancy.
目的 比较辅助生殖技术（ART）后单胎妊娠和双胎妊娠孕早期收集的β-人绒毛膜促性腺激素（β-hCG）和雌二醇水平。方法 我们前瞻性评估了最终分娩活产儿的50例单胎妊娠和47例双绒毛膜双胎妊娠。患者来自单一ART中心，采用标准治疗方案并进行新鲜胚胎移植。在狭窄的孕周范围内进行激素测量，并在单一实验室进行分析，从而将测定间和测定内的变异性降至最低。我们在胚胎移植后13天测量血清β-hCG，并在8 - 9周+6天测量β-hCG和雌二醇样本。结果 单胎和双胎在人口统计学和周期特征方面无显著差异。双胎的β-hCG和雌二醇均显著更高（P<0.05）。结论 数据证实双胎中β-hCG和雌二醇水平更高，表明这些胎盘激素在双胎妊娠早期支持中的潜在作用。
