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[人类心脏发育的超微结构方面。I. 人类胚胎心肌细胞的细胞骨架与运动性]

[Ultrastructural aspects in the development of the human heart. I. The cytoskeleton and motility of human embryonic myocardiocytes].

作者信息

Cotrutz C, Constantinov M, Ionescu C, Cotrutz C, Moraru M, Mărgineanu A, Indrei L, Grigoriu B D, Marta G

出版信息

Rev Med Chir Soc Med Nat Iasi. 1989 Apr-Jun;93(2):325-8.

PMID:2814049
Abstract

Electron microscopic investigations performed on heart tissue fragments from 12 human embryos. 8 to 15 weeks of age, showed that at the age of 8 weeks the myocardiocytes are poorly differentiated cells: they contain microfilaments of actin and myosin inserted on the cytoplasmic aspect of plasmalemma, a smooth endoplasmic reticulin and mitochondria, accounting for the early contraction. Gap junctions appear among myocardiocytes, confirming the myogenic theory of heart contractions. Within 10 to 15 weeks, actin and myosin myofilaments organize in sarcomeres. Eberth disks appear and numerous mitoses are to be seen.

摘要

对12例8至15周龄人类胚胎的心脏组织碎片进行电子显微镜研究,结果显示,8周龄时心肌细胞为分化程度低的细胞:它们含有插入质膜胞质面的肌动蛋白和肌球蛋白微丝、滑面内质网和线粒体,这是早期收缩的原因。心肌细胞之间出现缝隙连接,证实了心脏收缩的肌原性理论。在10至15周内,肌动蛋白和肌球蛋白肌丝在肌节中排列。埃伯斯盘出现,可见大量有丝分裂。

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