Cotrutz C, Constantinov M, Ionescu C, Cotrutz C, Moraru M, Marta G
Rev Med Chir Soc Med Nat Iasi. 1989 Jul-Sep;93(3):559-62.
Electronmicroscopic studies performed on atrial and ventricular tissue fragments from 9 human embryos, 8 to 15 weeks old, showed that in certain myocardiocytes, especially in the atrial ones, from the 10 weeks old embryos, there appear granules of secretion, very similar in morphology with those from adults, which had been demonstrated to contain the atrial natriuretic factor. The precocious appearance of this peptide represents a functional adaptation by which the embryo attempts at counterbalancing the actions of renin and angiotensin from the maternal circulation.
对9例8至15周龄人类胚胎的心房和心室组织碎片进行的电子显微镜研究表明，在某些心肌细胞中，尤其是10周龄胚胎的心房心肌细胞中，出现了分泌颗粒，其形态与成年人的分泌颗粒非常相似，已证实这些颗粒含有心房利钠因子。这种肽的过早出现是一种功能适应，胚胎试图通过这种适应来平衡来自母体循环的肾素和血管紧张素的作用。
