槐糖脂丁酯二乙酸酯不影响巨噬细胞极化，但在体外微摩尔浓度下可增强星形胶质细胞的胶质纤维酸性蛋白表达。
Sophorolipid Butyl Ester Diacetate Does Not Affect Macrophage Polarization but Enhances Astrocytic Glial Fibrillary Acidic Protein Expression at Micromolar Concentrations in Vitro.
作者信息
Ziemba Alexis M, Gottipati Manoj K, Totsingan Filbert, Hanes Cheryl M, Gross Richard A, Lennartz Michelle R, Gilbert Ryan J
机构信息
Department of Neuroscience and Center for Brain and Spinal Cord Repair, The Ohio State University , 460 W. 12th Avenue, Columbus, Ohio 43210, United States.
Center for Cell Biology and Cancer Research, Albany Medical College , 43 New Scotland Avenue Albany, New York 12208, United States.
出版信息
ACS Chem Neurosci. 2017 Apr 19;8(4):752-758. doi: 10.1021/acschemneuro.6b00451. Epub 2017 Feb 7.
Peritoneal macrophages (PMACs) and spinal cord astrocytes were exposed to varying concentrations of soluble sophorolipid butyl ester diacetate (SLBEDA) in vitro. Macrophages and astrocytes demonstrated no decrease in viability in response to SLBEDA. Studying pro- and anti-inflammatory genes, PMACs did not show a shift toward a pro-inflammatory phenotype. However, at higher concentrations (3 and 30 μM), astrocytes showed an increase in their expression of glial acidic fibrillary protein. This novel category of compounds poses low risk to PMAC and astrocyte viability; however, the effect on PMAC polarization and astrocyte reactivity requires more elucidation.
将腹膜巨噬细胞（PMACs）和脊髓星形胶质细胞在体外暴露于不同浓度的可溶性槐糖脂丁酯二乙酸酯（SLBEDA）。巨噬细胞和星形胶质细胞对SLBEDA的反应未显示活力下降。在研究促炎和抗炎基因时，PMACs未表现出向促炎表型的转变。然而，在较高浓度（3和30 μM）下，星形胶质细胞的胶质酸性纤维蛋白表达增加。这类新型化合物对PMAC和星形胶质细胞活力的风险较低；然而，对PMAC极化和星形胶质细胞反应性的影响需要更多阐释。
Zotero 插件